Univariate and multivariable Cox model results describing associations between baseline clinical variables and progression-free survival
| Hazard ratio | 95% CI | p-value | |
| Univariate analysis | |||
| New York Heart Association stage | 2.083 | 1.250–3.470 | 0.0048# |
| Mean pulmonary arterial pressure (mmHg) | 1.039 | 1.013–1.065 | 0.0028# |
| Pulmonary capillary pressure (mmHg) | 1.043 | 0.923–1.180 | 0.4969 |
| Cardiac output (L·min−1) | 1.267 | 0.996–1.612 | 0.0535# |
| Pulmonary vascular resistance (Wood's units) | 1.008 | 0.952–1.067 | 0.7796 |
| Right atrium pressure (mmHg) | 1.194 | 1.048–1.359 | 0.0075# |
| 6-min walk test | |||
| Distance (m) | 0.996 | 0.993–0.999 | 0.0080# |
| Distance (m) >440 m versus ≤440 m | 0.398 | 0.166–0.954 | 0.0389# |
| Borg test | 1.006 | 0.858–1.179 | 0.9421 |
| Cardiac frequency (bpm) | |||
| Baseline | 1.004 | 0.947–1.064 | 0.9011 |
| End | 1.018 | 0.985–1.053 | 0.2852 |
| Oxygen saturation (%) | |||
| Baseline | 0.896 | 0.821–0.977 | 0.0132# |
| End | 0.937 | 0.902–0.974 | 0.0010# |
| Δ≥4% | 4.144 | 0.534–32.16 | 0.1739 |
| SF-36 Questionnaire | |||
| Physical functioning | 0.981 | 0.966–0.996 | 0.0142# |
| Role-physical | 0.986 | 0.975–0.998 | 0.0212# |
| Bodily pain | 0.991 | 0.975–1.008 | 0.3053 |
| General health | 0.987 | 0.965–1.009 | 0.2436 |
| Vitality | 0.977 | 0.953–1.002 | 0.0705# |
| Social functioning | 0.983 | 0.968–0.998 | 0.0304# |
| Role-emotional | 0.988 | 0.978–0.998 | 0.0199# |
| Mental health | 0.976 | 0.955–0.997 | 0.0267# |
| Multivariate analysis | |||
| SF-36 Questionnaire: physical functioning | 0.978 | 0.962–0.995 | 0.0106 |
| Mean pulmonary arterial pressure (mmHg) | 1.053 | 1.023–1.084 | 0.0153 |
| Cardiac output (L·min−1) | 1.559 | 1.189–2.045 | 0.0013 |
Δ≥4%: change in oxygen saturation over 4%; SF-36: 36-item Short-Form Health Survey. #: variables with a univariate p<0.15 were retained for multivariable analysis.