CTEPH (n=19) | PAH (n=18) | p-values | |||
Patients with available data | Baseline values | Patients with available data | Baseline values | ||
Age, years | 19 | 50.7±10.1 | 18 | 46.7±13.2 | 0.305 |
Female | 19 | 11 (58) | 18 | 13 (72) | 0.362 |
BMI, kg·m−2 | 19 | 24.4±3.0 | 18 | 23.0±3.7 | 0.214 |
Laboratory tests | |||||
Haemoglobin, g·L−1 | 19 | 149 (144–163) | 18 | 143 (128–153) | 0.049 |
Platelets, ×109 cells·L−1 | 19 | 207 (170–240) | 18 | 160 (121–203) | 0.020 |
Albumin, g·L−1 | 19 | 36.5 (33.4–40.8) | 18 | 38.6 (34.6–40.6) | 0.518 |
AST, U·L−1 | 19 | 29.6±7.5 | 18 | 30.8±9.1 | 0.649 |
ALT, U·L−1 | 19 | 24.0 (15.0–35.0) | 18 | 26.5 (20.0–37.8) | 0.313 |
γ-GT, U·L−1 | 19 | 60 (40–108) | 18 | 57.5 (32.5–100) | 0.461 |
Total bilirubin, μmol·L−1 | 19 | 21.0±10.8 | 18 | 15.9±6.5 | 0.094 |
Creatinine, μmol·L−1 | 19 | 82.3±20.3 | 18 | 72.8±19.3 | 0.642 |
NT-proBNP, pg·mL−1 | 15 | 1505 (643–3430) | 9 | 472 (155–1106) | 0.035 |
6MWD, m | 19 | 355±83 | 18 | 363±41 | 0.719 |
WHO FC I/II/III/IV | 19 | 2/9/8/0 | 18 | 1/13/4/0 | 0.641 |
Echocardiography | |||||
RV transverse diameter, mm | 15 | 48.2±9.2 | 14 | 45.9±6.8 | 0.462 |
LV transverse diameter, mm | 11 | 28.8 (23.0–39.0) | 11 | 29.3 (24.1–30.1) | 0.949 |
RV/LV | 11 | 1.8±0.7 | 11 | 1.7±0.5 | 0.512 |
RA transverse diameter, mm | 15 | 59.0 (45.5–60.6) | 14 | 50.1 (41.2–56.7) | 0.354 |
LA transverse diameter, mm | 15 | 30.2 (25.3–35.5) | 14 | 27.2 (26.8–31.4) | 0.451 |
Thickness of RVAW, mm | 14 | 6.0 (5.3–7.2) | 14 | 5.8 (4.9–8.4) | 0.734 |
Amplitude of RVAW motion, mm | 13 | 1.0 (1.0–5.0) | 14 | 3.5 (2.8–5.4) | 0.068 |
MPA diameter, mm | 14 | 31.7 (28.6–34.7) | 14 | 31.8 (28.4–35.0) | 0.874 |
TRV, m·s−1 | 15 | 4.7±0.4 | 14 | 4.3±0.5 | 0.046 |
Estimated systolic PAP, mmHg | 15 | 99.5±16.0 | 14 | 87.3±17.0 | 0.056 |
Haemodynamic parameters | |||||
CVP, mmHg | 19 | 9.4±6.0 | 18 | 7.1±6.1 | 0.251 |
Systolic PAP, mmHg | 19 | 88.8±15.1 | 18 | 85.0±22.0 | 0.543 |
Diastolic PAP, mmHg | 19 | 32 (26–38) | 18 | 35 (28–40) | 0.391 |
Mean PAP, mmHg | 19 | 54 (45–59) | 18 | 51 (42–63) | 0.869 |
PAWP, mmHg | 19 | 8.5±2.0 | 18 | 8.6±3.1 | 0.872 |
Cardiac output, L·min−1 | 19 | 3.0±0.9 | 18 | 2.9±0.5 | 0.703 |
Cardiac index, L·min−1·m−2 | 19 | 1.7 (1.3–2.0) | 18 | 1.8 (1.5–2.1) | 0.425 |
PVR, dyn·s·cm–5 | 19 | 1245±396 | 18 | 1272±446 | 0.847 |
SvO2, % | 13 | 61.3±11.3 | 13 | 68.1±10.1 | 0.124 |
Data are presented as n, mean±sd, n (%) or median (interquartile range), unless otherwise stated. CTEPH: chronic thromboembolic pulmonary hypertension; PAH: pulmonary arterial hypertension; BMI: body mass index; AST: aspartate aminotransferase; ALT: alanine amino transferase; γ-GT: γ-glutamyl transferase; NT-proBNP: N-terminal pro-brain natriuretic peptide; 6MWD: 6-min walk distance; WHO FC: World Health Organization functional class; RV: right ventricle; LV: left ventricle; RV/LV: the ratio of right ventricle to left ventricle dimension; RA: right atrium; LA: left atrium; RVAW: right ventricular anterior wall; MPA: main pulmonary artery; TRV: tricuspid regurgitation velocity; PAP: pulmonary artery pressure; CVP: central venous pressure; PAWP: pulmonary artery wedge pressure; PVR: pulmonary vascular resistance; SvO2: mixed venous oxygen saturation.