TABLE 1

Baseline characteristics of the study population

CTEPH (n=19)PAH (n=18)p-values
Patients with available dataBaseline valuesPatients with available dataBaseline values
Age, years1950.7±10.11846.7±13.20.305
Female1911 (58)1813 (72)0.362
BMI, kg·m−21924.4±3.01823.0±3.70.214
Laboratory tests
 Haemoglobin, g·L−119149 (144–163)18143 (128–153)0.049
 Platelets, ×109 cells·L−119207 (170–240)18160 (121–203)0.020
 Albumin, g·L−11936.5 (33.4–40.8)1838.6 (34.6–40.6)0.518
 AST, U·L−11929.6±7.51830.8±9.10.649
 ALT, U·L−11924.0 (15.0–35.0)1826.5 (20.0–37.8)0.313
 γ-GT, U·L−11960 (40–108)1857.5 (32.5–100)0.461
 Total bilirubin, μmol·L−11921.0±10.81815.9±6.50.094
 Creatinine, μmol·L−11982.3±20.31872.8±19.30.642
 NT-proBNP, pg·mL−1151505 (643–3430)9472 (155–1106)0.035
 6MWD, m19355±8318363±410.719
 WHO FC I/II/III/IV192/9/8/0181/13/4/00.641
Echocardiography
 RV transverse diameter, mm1548.2±9.21445.9±6.80.462
 LV transverse diameter, mm1128.8 (23.0–39.0)1129.3 (24.1–30.1)0.949
 RV/LV111.8±0.7111.7±0.50.512
 RA transverse diameter, mm1559.0 (45.5–60.6)1450.1 (41.2–56.7)0.354
 LA transverse diameter, mm1530.2 (25.3–35.5)1427.2 (26.8–31.4)0.451
 Thickness of RVAW, mm146.0 (5.3–7.2)145.8 (4.9–8.4)0.734
 Amplitude of RVAW motion, mm131.0 (1.0–5.0)143.5 (2.8–5.4)0.068
 MPA diameter, mm1431.7 (28.6–34.7)1431.8 (28.4–35.0)0.874
 TRV, m·s−1154.7±0.4144.3±0.50.046
 Estimated systolic PAP, mmHg1599.5±16.01487.3±17.00.056
Haemodynamic parameters
 CVP, mmHg199.4±6.0187.1±6.10.251
 Systolic PAP, mmHg1988.8±15.11885.0±22.00.543
 Diastolic PAP, mmHg1932 (26–38)1835 (28–40)0.391
 Mean PAP, mmHg1954 (45–59)1851 (42–63)0.869
 PAWP, mmHg198.5±2.0188.6±3.10.872
 Cardiac output, L·min−1193.0±0.9182.9±0.50.703
 Cardiac index, L·min−1·m−2191.7 (1.3–2.0)181.8 (1.5–2.1)0.425
 PVR, dyn·s·cm–5191245±396181272±4460.847
SvO2, %1361.3±11.31368.1±10.10.124

Data are presented as n, mean±sd, n (%) or median (interquartile range), unless otherwise stated. CTEPH: chronic thromboembolic pulmonary hypertension; PAH: pulmonary arterial hypertension; BMI: body mass index; AST: aspartate aminotransferase; ALT: alanine amino transferase; γ-GT: γ-glutamyl transferase; NT-proBNP: N-terminal pro-brain natriuretic peptide; 6MWD: 6-min walk distance; WHO FC: World Health Organization functional class; RV: right ventricle; LV: left ventricle; RV/LV: the ratio of right ventricle to left ventricle dimension; RA: right atrium; LA: left atrium; RVAW: right ventricular anterior wall; MPA: main pulmonary artery; TRV: tricuspid regurgitation velocity; PAP: pulmonary artery pressure; CVP: central venous pressure; PAWP: pulmonary artery wedge pressure; PVR: pulmonary vascular resistance; SvO2: mixed venous oxygen saturation.