Age- and sex-adjusted endostatin associations with survival in the PAH Biobank cohort, overall and by disease subtype

Univariable HRMultivariable adjusted HR#
Overall cohort3.52 (2.75–4.50, <0.001)2.32 (1.56–3.45, <0.001)
CTD-PAH subgroup2.91 (1.93–4.38, <0.001)1.76 (0.94–3.32, 0.080)
IPAH subgroup6.44 (4.16–9.98, <0.001)5.68 (2.4–12.8, <0.001)

Values are presented as hazard ratio (HR) (95% confidence interval, p-value) per log endostatin. PAH: pulmonary arterial hypertension; CTD-PAH: connective tissue disease-associated PAH; IPAH: idiopathic PAH; NYHA FC: New York Heart Association Functional Class; 6MWD: 6-min walking distance; RAP: right atrial pressure; mPAP: mean pulmonary arterial pressure; PVR: pulmonary vascular resistance. #: multivariable models are adjusted for age, sex, PAH-specific therapy, NYHA FC, 6MWD, RAP, mPAP, confidence interval and PVR.