TABLE 5

Univariable and multivariable hazard ratios (HRs) for each of the categorical REVEAL 2.0 risk parameters and endostatin greater than the median

REVEAL parametersUnadjusted HR (95% CI)p-valueAdjusted# HR (95% CI)p-value
CTD-PAH1.51 (1.21–1.89)<0.0010.90 (0.57–1.44)0.673
Portopulmonary hypertension2.19 (1.54–3.11)<0.0011.84 (0.81–4.21)0.146
Heritable PAH0.65 (0.34–1.27)0.2071.44 (0.33–6.21)0.627
Male >60 years1.94 (1.40–2.69)<0.0010.79 (0.37–1.71)0.554
NYHA/WHO
 FC I0.59 (0.25–1.37)0.2220.27 (0.04–2.08)0.210
 FC IIrefref
 FC III1.82 (1.34–2.47)<0.0011.00 (0.55–1.82)0.997
 FC IV1.92 (1.20–3.09)0.0070.97 (0.41–2.30)0.951
SBP <110 mmHg0.71 (0.48–1.03)0.0690.81 (0.42–1.55)0.518
Heart rate >96 beats per min0.77 (0.50–1.20)0.2550.63 (0.29–1.34)0.231
6MWD
 <165 m1.75 (1.12–2.71)0.0131.28 (0.71–2.32)0.415
 165−<320 mrefref
 320−<440 m0.56 (0.39–0.80)0.0020.69 (0.41–1.18)0.178
 ≥440 m0.35 (0.21–0.59)<0.0010.45 (0.18–1.11)0.082
NTproBNP
 <300 pg·mL−10.49 (0.32–0.74)0.0010.52 (0.21–1.25)0.145
 300−<1100 pg·mL−1refref
 ≥1100 pg·mL−13.10 (2.35–4.08)<0.0013.16 (1.70–5.89)<0.001
RAP >20 mmHg1.93 (1.23–3.04)0.0040.93 (0.40–2.12)0.861
PVR <5 Wood units1.08 (0.82–1.43)0.571.15 (0.64–2.04)0.641
Endostatin
 <medianrefref
 >median2.76 (2.17–3.51)<0.0012.47 (1.39–4.39)0.002

PAH: pulmonary arterial hypertension; CTD-PAH: connective tissue disease-associated PAH; IPAH: idiopathic PAH; NYHA FC: New York Heart Association Functional Class; WHO: World Health Organization; SBP: systolic blood pressure; 6MWD: 6-min walking distance; NTproBNP: N-terminal pro-brain natriuretic peptide; RAP: right atrial pressure; PVR: pulmonary vascular resistance. #: adjusted for all other REVEAL variables plus endostatin.