TABLE 1

Eligibility criteria

Inclusion criteriaExclusion criteria
Aged 5 to 15 yearsHospital admission (≥24 h) for asthma in the last 12 months
Doctor diagnosis of asthma (parent/participant or doctor-reported) ANDSelf-reported use of >6 SABA inhalers in the last 12 months (i.e. poor-control)
 SABA use on three or more consecutive days in the last 12 months, AND/ORAny use of ICS, LABA, LTRA, theophylline, anticholinergic agent or cromone in the last 6 months
 SABA use on two or more days per month, on average, in the last 12 months, AND/ORAny use of systemic corticosteroids in the last 6 weeks
 Urgent medical review for worsening asthma in the last 12 monthsAny medical condition which, at the Investigator's discretion, may present a safety risk or impact the feasibility of the study or the study results (including, but not limited to, other significant respiratory comorbidities, such as cystic fibrosis and bronchiectasis)
Registered with a General PractitionerAny known or suspected contraindications to the medications prescribed in the study or their respective excipients
Previous life-threatening asthma (intensive care unit admission)
Unable or unwilling to switch from current asthma treatment regimen
Unable or unwilling to provide written informed consent (parent(s)/guardian(s)) or assent/consent (participant)
Self-reported current pregnancy or breastfeeding at the time of enrolment

SABA: short-acting β2-agonist; ICS: inhaled corticosteroid; LABA: long-acting β2-agonist; LTRA: leukotriene receptor antagonist.