TABLE 4

Univariable and multivariable hazard ratios (HRs) for each of the European Society of Cardiology/European Respiratory Society (ESC/ERS) low-risk parameters and endostatin less than the median

ESC/ERS low-risk criteriaUnadjusted HR (95% CI)p-valueAdjusted# HR (95% CI)p-value
Functional Class I–II0.51 (0.38–0.68)<0.0010.62 (0.41–0.94)0.024
6-min walk distance >440 m0.40 (0.24–0.66)<0.0010.66 (0.36–1.20)0.174
RAP <8 mmHg0.81 (0.65–1.02)0.0730.78 (0.54–1.14)0.203
Cardiac index ≥2.5 L·min−1·m−20.97 (0.78–1.21)0.7781.01 (0.71–1.44)0.955
NTproBNP <300pg·mL−10.23 (0.16–0.33)<0.0010.27 (0.15–0.47)<0.001
Endostatin <median0.36 (0.28–0.46)<0.0010.42 (0.28–0.64)<0.001

RAP: right atrial pressure; NTproBNP: N-terminal pro-brain natriuretic peptide. #: adjusted for all other variables including biomarkers (NTproBNP <300 pg·mL−1 and endostatin <median).