TABLE 2

Change in measures that met responsiveness criteria over 60 weeks by health transition question (SF2) categorical responses in patients with idiopathic pulmonary fibrosis in the Prednisone, Azathioprine, and N-Acetylcysteine: A Study That Evaluates Response in Idiopathic Pulmonary Fibrosis (PANTHER-IPF) trial

	SF2 response at 60-week follow-up					AUC (95% CI)^¶
	Much better	Somewhat better	About the same	Somewhat worse^#	Much worse	AUC (95% CI)^¶
Subjects n	11	32	101	74	10
Physiological measures
ΔSF-36 physical component score⁺	8.00±11.57	−0.92±6.26	−0.06±5.72	−6.79±8.07	−5.29±9.26	0.75 (0.67–0.83)
Subjective measures
ΔTotal SGRQ score^§	−13.70±14.55	−0.97±9.60	1.35±9.18	10.95±13.19	25.86±17.46	0.71 (0.63–0.79)
ΔUCSD SOBQ total score	−4.45±11.79	3.19±9.60	0.59±12.81	11.38±15.31	34.90±23.65	0.72 (0.65–0.80)

Data are presented as mean±sd, unless otherwise stated. AUC: area under the curve; Δ: absolute change over 60 weeks; SF-36: 36-Item Short-Form Health Survey; SGRQ: St George's Respiratory Questionnaire; UCSD SOBQ: University of California, San Diego Shortness of Breath Questionnaire. ^#: the mean change in scores in the “somewhat worse” category is the minimal clinically important difference value for measures that meet the responsiveness criteria; ^¶: receiver operating curve comparing dichotomous health transition question (SF2) response (“about the same” versus “somewhat worse”) with mean change score of variable; ⁺: missing n=5 (0 “much better”, 1 “somewhat better”, 4 “about the same”, 0 “somewhat worse”, 0 “much worse”); ^§: missing n=13 (0 “much better”, 2 “somewhat better”, 8 “about the same”, 3 “somewhat worse”, 0 “much worse”).