TABLE 1

Change in measures that met responsiveness criteria over 24 weeks by health transition question (SF2) categorical responses in patients with idiopathic pulmonary fibrosis in the Sildenafil Trial of Exercise Performance in Idiopathic Pulmonary Fibrosis (STEP-IPF) trial

SF2 response at 24-week follow-upAUC (95% CI)
Much betterSomewhat betterAbout the sameSomewhat worse#Much worse
Subjects n71246589
Physiological measures
 Δ6MWD m−3.71±42.33−35.08±144.51−32.29±95.46−74.89±69.32−163.00±122.930.72 (0.61–0.83)

Data are presented as mean±sd, unless otherwise stated. AUC: area under the curve; Δ: absolute change over 24 weeks; 6MWD: 6-min walk distance. #: the mean change in scores in the “somewhat worse” category is the minimal clinically important difference value for measures that meet the responsiveness criteria; : receiver operating curve comparing dichotomous health transition question (SF2) response (“about the same” versus “somewhat worse”) with mean change score of variable.