TABLE 3

Mixed effects multivariable regression models for longitudinal FEV₁, FVC and FEV₁/FVC change with CT measurements

Interactions	Estimate (95% CI)	se	p-value
FEV₁, mL
TAC×time	−0.052	0.058	0.37
Pi10×time	−15.80	25.14	0.53
Wall area percent×time	−0.70	1.40	0.62
LAA₈₅₆×time	−0.32	0.26	0.22
FVC, mL
TAC×time	−0.18	0.08	0.02
Pi10×time	−42.37	36.00	0.24
Wall area percent×time	0.73	1.97	0.71
LAA₈₅₆×time	−0.36	0.36	0.33
FEV₁/FVC, %
TAC×time	0.003	0.001	0.03
Pi10×time	−0.67	0.49	0.17
Wall area percent×time	−0.03	0.03	0.33
LAA₈₅₆×time	−0.002	0.005	0.75

Models included: time, Visit 1 age (years), sex (female), height (cm), Caucasian race, smoking status, pack-years, LAA₉₅₀ (%), CT model. FEV₁ (mL), FVC (mL) and FEV₁/FVC (%), and the interaction of the measurements with time, were included in models for FEV₁, FVC and FEV₁/FVC, respectively. CT air volume/total lung capacity (%) was used for TAC, Pi10 and wall area percent and CT air volume/residual volume (%) was used for LAA₈₅₆.