TABLE 1

Patient characteristics and follow-up findings

AllNormalLate OP patternFibrosisp-value
Subjects n43121912
Age, years56.0 (50.5–64.0)56.0 (46.0–63.3)55.0 (51.5–64.0)62.0 (50.5–63.5)0.816
Male gender32/43 (74)9/12 (75)13/19 (68)10/12 (83)0.755
Smoker13/39 (33)6/11 (55)3/16 (19)4/12 (33)0.149
Comorbidities
 Diabetes21/43 (49)6/12 (50)12/19 (63)3/12 (25)0.146
 Hypertension17/43 (39)5/12 (42)8/19 (42)4/12 (33)0.925
 Obesity10/43 (23)3/12 (25)5/19 (26)2/12 (17)0.902
 Cardiovascular disease11/43 (26)3/12 (25)7/19 (37)1/12 (8)0.222
 Chronic respiratory disease3/43 (7)1/12 (8)0/19 (0)2/12 (17)0.164
 Cancer8/43 (19)5/12 (42)2/19 (11)1/12 (8)0.066
Disease extent on initial CT scan0.003
 <50%19/33 (58)9/9 (100)7/13 (54)3/11 (27)
 >50%14/33 (42)0/9 (0)6/13 (46)8/11 (73)
Length of ICU stay, days15 (9–32)12 (3–17)19 (11–32)24 (11–49)0.179
Tracheal intubation33/43 (77)8/12 (67)14/18 (78)11/12 (92)0.404
Delay between ICU admission and follow-up CT, months7.1 (5.9–9.1)7.5 (6.4–9.8)6.8 (6.0–8.7)7.3 (5.5–9.2)0.668
CT findings
 Ground-glass opacities29/43 (67)0 (0)17/19 (89)12/12 (100)
 Parenchymal bands26/43 (60)0 (0)15/19 (79)10/12 (83)
 Traction bronchiectasis12/43 (28)0 (0)0 (0)12/12 (100)
 Reticulations5/43 (12)0 (0)0 (0)5/12 (42)
Delay between ICU admission and follow-up PFTs, months7.9 (6.2–10.0)8.1 (6.4–10.1)6.8 (5.8–8.5)10.0 (8.3–10.8)0.024
Follow-up PFTs results
 Impaired TLC4/39 (10)1/9 (11)0/19 (0)3/11 (27)0.035
 % of predicted TLC93 (85–96)93 (90–96)93 (88–96)93 (81–98)0.693
 Impaired FVC6/39 (14)1/9 (11)1/19 (5)4/11 (36)0.073
 % of predicted FVC94 (83–105)97 (87–99)94 (84–105)94 (74–105)0.810
 Impaired DLCO31/38 (82)6/9 (67)16/18 (89)9/11 (82)0.361
 % of predicted DLCO64 (50–76)78 (67–83)64 (51–75)61 (45–70)0.138

Quantitative data are presented as median (interquartile range) and qualitative data are presented as n/N (%). OP: organising pneumonia; CT: computed tomography; ICU: intensive care unit; PFTs: pulmonary function tests; FVC: forced vital capacity; TLC: total lung capacity; DLCO: diffusing capacity of the lung for the lung monoxide.