TABLE 6

Standardised regression coefficients and 95% confidence intervals (in brackets) regarding the associations between anxiety and depression in caregivers and health-related quality of life in their child/adolescent with PCD

Health-related quality of life (QOL-PCD) domains		Anxiety (GAD-7)	Depression (PHQ-9)
Physical Functioning	Crude	−0.12 (−0.46 to 0.22) p=0.48	−0.39 (−0.69 to −0.09) p=0.01
	Adjusted	−0.21 (−0.67 to 0.26) p=0.38	−0.50 (−0.82 to −0.18) p=0.002
Emotional Functioning	Crude	0.27 (−0.11 to 0.66) p=0.17	−0.13 (−0.49 to 0.23) p=0.47
	Adjusted	0.32 (−0.10 to 0.74) p=0.14	−0.15 (−0.51 to 0.20) p=0.40
Treatment Burden	Crude	0.24 (−0.13 to 0.61) p=0.21	−0.17 (−0.49 to 0.16) p=0.32
	Adjusted	0.25 (−0.13 to 0.63) p=0.20	−0.18 (−0.50 to 0.14) p=0.27
Social Functioning	Crude	0.05 (−0.31 to 0.41) p=0.80	0.10 (−0.21 to 0.41) p=0.53
	Adjusted	0.07 (−0.45 to 0.59) p=0.79	0.09 (−0.38 to 0.56) p=0.72
Upper Respiratory Symptoms	Crude	0.10 (−0.27 to 0.46) p=0.61	0.02 (−0.31 to 0.35) p=0.91
	Adjusted	0.21 (−0.37 to 0.78) p=0.49	0.15 (−0.29 to 0.60) p=0.49
Lower Respiratory Symptoms	Crude	0.07 (−0.30 to 0.44) p=0.71	0.08 (−0.25 to 0.42) p=0.63
	Adjusted	0.28 (−0.56 to 1.11) p=0.52	0.27 (−0.27 to 0.81) p=0.33
Hearing Symptoms	Crude	−0.12 (−0.44 to 0.19) p=0.45	−0.03 (−0.38 to 0.32) p=0.85
	Adjusted	−0.13 (−0.44 to 0.19) p=0.44	−0.08 (−0.43 to 0.28) p=0.68

Adjusted: adjusted for gender, age, FEV₁ and BMI. PCD: primary ciliary dyskinesia; GAD-7: Generalised Anxiety Disorder 7-Item; PHQ-9: Patient Health Questionnaire-9; FEV₁: forced expiratory volume in 1 s, expressed as percentage of the predicted value; BMI: body mass index; QOL-PCD: Quality of Life Instrument for Primary Ciliary Dyskinesia.