TABLE 3

Differences in dynamic contrast-enhanced parameters between idiopathic pulmonary fibrosis and healthy control groups

Unadjusted model estimate# (95% CI)p-valueAge-adjusted model estimate# (95% CI)p-value
Peak enhancement (%)
 Lower axial−83 (−130– −33)0.003−71 (−140– −1.4)0.055
 Middle axial−52 (−97– −8.3)0.027−36 (−97–24)0.25
 Upper axial−55 (−100– −9.5)0.024−26 (−88–35)0.41
 Posterior coronal−72 (−130– −14)0.020−34 (−110–42)0.38
 Whole lung−65 (−110– −21)0.007−42 (−100–18)0.18
TTP (min)
 Lower axial0.020 (−0.008–0.049)0.170.029 (−0.010–0.068)0.15
 Middle axial0.021 (−0.003–0.046)0.100.021 (−0.012–0.055)0.22
 Upper axial0.017 (−0.007–0.040)0.170.021 (−0.011–0.053)0.22
 Posterior coronal0.027 (0.001–0.052)0.0470.030 (−0.003–0.065)0.098
 Whole lung0.021 (−0.001–0.044)0.0750.025 (−0.006–0.056)0.12
kwashin (%·min−1)
 Lower axial−500 (−740– −270)<0.001−510 (−830– −190)0.004
 Middle axial−360 (−620– −91)0.013−340 (−700–22)0.076
 Upper axial−400 (−660– −150)0.004−340 (−690–13)0.069
 Posterior coronal−490 (−740– −240)0.001−380 (−720– −38)0.037
 Whole lung−440 (−660– −220)<0.001−390 (−700– −88)0.017
kwashout (%·min−1)
 Lower axial9.5 (2.1–17)0.01710.4 (0.3–20.5)0.054
 Middle axial4.7 (−1.0–10)0.126.4 (−1.5–14.2)0.12
 Upper axial4.6 (−2.2–11)0.206.5 (−2.9–15.9)0.19
 Posterior coronal8.4 (1.5–15)0.0237.2 (−2.3–16.8)0.15
 Whole lung6.8 (0.6–13)0.0417.6 (−1.0–16.2)0.093
AUC60 (%·s−1)
 Lower axial−940 (−2600–710)0.27−930 (−3200–1400)0.43
 Middle axial−55 (−1500–1400)0.94560 (−1400–2500)0.57
 Upper axial−240 (−1900–1400)0.78980 (−1200–3200)0.39
 Posterior coronal−850 (−2810–1100)0.40470 (−2200–3100)0.73
 Whole lung−520 (2100–1000)0.51270 (−1800–2400)0.80

Model intercepts and estimates for age available on request from the authors. TTP: time to peak; kwashin: rate of contrast arrival; kwashout: rate of contrast clearance; AUC60: area under the dynamic curve in the first 60 s. #: estimates denote expected differences between idiopathic pulmonary fibrosis and healthy control subjects.