TABLE 4

The associations between asthma onset phenotypes and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) positive test stratified by sex, baseline smoking, obesity and ethnicity (NEW)

Percentage of positive tests (n/N)OR (95% CI) for a positive testPercentage of positive tests (n/N)OR (95% CI) for a positive testp-value for interaction
MaleFemaleSex
Asthma onset0.53
 No asthma17.2 (7374/42 981)Ref16.3 (7973/48 996)Ref
 Early-onset (<13 years)15.5 (417/2684)0.86 (0.76–0.97), p=0.0116.8 (470/2785)0.94 (0.83–1.06), p=0.330.29
 Late onset (≥13 years)18.1 (626/3464)1.00 (0.91–1.11), p=0.8816.9 (1023/6055)0.99 (0.92–1.08), p=0.950.75
Never smokedEver smokedSmoking
Asthma onset0.71
 No asthma16.9 (8156/48 191)Ref16.4 (7152/43 479)Ref
 Early-onset (<13 years)16.5 (495/3003)0.87 (0.78–0.98), p=0.0216.0 (399/2497)0.94 (0.84–1.07), p=0.400.45
 Late onset (≥13 years)17.4 (819/4711)1.00 (0.91–1.09), p=0.8617.2 (793/4589)1.00 (0.91–1.09), p=0.970.79
Normal weightOverweight/ObeseBMI
Asthma onset0.03
 No asthma14.8 (4202/28 226)Ref17.4 (11 036/63 271)Ref
 Early-onset (<13 years)16.1 (264/1634)1.09 (0.94–1.27), p=0.2216.2 (625/3854)0.85 (0.77–0.93), p=0.0010.01
 Late onset (≥13 years)14.4 (330/2280)0.94 (0.82–1.08), p=0.4318.2 (1293/7070)1.02 (0.94–1.09), p=0.590.41
Non-blackBlackEthnicity
Asthma onset0.32
 No asthma16.5 (14 900/90 327)Ref27.1 (444/1637)Ref
 Early-onset (<13 years)15.9 (859/5389)0.90 (0.82–0.98), p=0.0134.6 (27/78)1.54 (0.90–2.6), p=0.110.14
 Late onset (≥13 years)17.1 (1601/9355)0.99 (0.93–1.06), p=0.8931.1 (51/164)1.18 (0.79–1.7), p=0.400.67

Adjusted for age at recruitment, sex, and baseline measures of: education, average household income, smoking history, BMI, ethnicity, white blood cell count, eosinophil count, close to major road and greenspaces buffer. Bold values indicate p-value <0.05.