TABLE 4

Effect sizes of the primary (Cambridge Neuropsychological Test Automated Battery, CANTAB) outcome measures

Test	Measure	Phase 1			Phase 2
		F time	F group	F int.	F time	F group	F int.
MOT	Mean latency (ms)	0.21	0.35	0.84	0.44	0.09	0.36
PAL	Total errors (n)	1.23	0.31	3.79	4.63*	0.35	0.88
	Adjusted total errors (n)	3.79	1.09	0.30	0.68	0.67	0.01
	First attempt memory score	0.58	0.45	1.16	1.82	0.67	2.32
SST	Stop-signal reaction time (ms)	0.04	4.76*	0.39	2.88	4.41*	0.78
RTI	Median simple reaction time (ms)	1.96	1.30	0.00	7.53**	2.47	0.26
	Mean simple movement time (ms)	2.61	0.42	3.73	2.96	1.20	0.02
	Median five-choice reaction time (ms)	0.88	0.00	2.47	9.13**	0.77	0.27
	Mean five-choice movement time (ms)	1.10	0.05	0.01	1.00	0.17	6.20*
DMS	Correct responses (%)	1.25	1.12	0.00	1.91	0.99	0.04
	Median correct latency (ms)	2.11	0.63	0.11	0.23	0.22	1.31
	Probability of error given error (%)	0.13	0.51	4.63*	0.00	1.15	1.06
SWM	Between-errors (n)	0.04	0.10	1.91	0.55	1.25	3.54
	Between-errors 4 boxes (n)	0.14	0.52	0.01	0.16	0.14	2.54
	Between-errors 6 boxes (n)	0.10	0.41	0.14	1.28	1.83	1.87
	Between-errors 8 boxes (n)	0.02	0.09	1.92	0.19	0.78	2.65
	Strategy	0.40	0.25	1.12	0.10	0.46	2.05

int.: interaction; MOT: motor orientation task; PAL: paired associates learning; SST: stop-signal task; RTI: reaction time task; DMS: delayed match-to-sample; SWM: spatial working memory. All data expressed as F-values. *p<0.05. **p<0.01.