Descriptive statistics of the primary (Cambridge Neuropsychological Test Automated Battery, CANTAB) outcome measures
| Test | Measure | T1 | T2 | T3 | |||
| Intervention | Placebo | Intervention | Placebo | Intervention | Placebo | ||
| MOT | Mean latency (ms) | 896 (696–1031) | 894 (761–1056) | 903 (755–980) | 865 (736–961) | 860 (771–940) | 827 (745–976) |
| PAL | Total errors (n) | 13.0 (11.0–20.0) | 13.0 (8.0–17.0) | 13.0 (10.0–16.0) | 13.0 (11.0–17.0) | 13.0 (9.0–18.0) | 13.0 (9.0–21.0) |
| Adjusted total errors (n) | 20.0 (12.0–39.0) | 19.0 (10.0–41.0) | 14.0 (10.0–42.0) | 16.0 (11.0–24.0) | 17.0 (9.0–36.0) | 14.5 (9.0–21.0) | |
| First attempt memory score | 9.76±3.83 | 10.55±4.56 | 10.89±4.34 | 10.56±3.53 | 10.88±3.17 | 12.27±3.06 | |
| SST | Stop-signal reaction time (ms) | 244 (220–272) | 240 (213–275) | 258 (240–276) | 236 (215–262) | 249 (224–267) | 223 (208–253) |
| RTI | Median simple reaction time (ms) | 328 (308–349) | 340 (316–366) | 331 (311–350) | 349 (325–365) | 341 (320–361) | 361 (338–386) |
| Mean simple movement time (ms) | 253 (216–286) | 243 (207–302) | 250 (225–288) | 264 (229–313) | 272 (214–303) | 272 (223–326) | |
| Median five-choice reaction time (ms) | 399 (366–429) | 392 (370–412) | 399 (366–426) | 392 (358–425) | 425 (382–441) | 419 (379–450) | |
| Mean five-choice movement time (ms) | 290 (240–313) | 283 (245–331) | 282 (271–339) | 309 (258–331) | 272 (239–312) | 307 (250–336) | |
| DMS | Correct responses (%) | 85.0 (80.0–90.0) | 85.0 (75.0–90.0) | 90.0 (85.0–95.0) | 85.0 (75.0–95.0) | 85.0 (80.0–95.0) | 85.0 (77.5–92.5) |
| Median correct latency (ms) | 3027 (2494–3370) | 3294 (2593–3488) | 3003 (2478–4305) | 3255 (2475–4342) | 3295 (2411–4243) | 3159 (2534–4490) | |
| Probability of error given error (%) | 0.0 (0.0–20.0) | 0.0 (0.0–16.7) | 0.0 (0.0–0.0) | 0.0 (0.0–20.0) | 0.0 (0.0–25.0) | 0.0 (0.0–21.0) | |
| SWM | Between-errors (n) | 16.0 (6.0–21.0) | 15.0 (6.0–23.0) | 15.0 (7.0–20.0) | 17.0 (10.0–20.0) | 16.0 (9.0–21.0) | 12.0 (4.0–19.0) |
| Between-errors 4 boxes (n) | 0.0 (0.0–1.0) | 0.0 (0.0–2.0) | 0.0 (0.0–0.0) | 0.0 (0.0–1.0) | 0.0 (0.0–2.0) | 0.0 (0.0–0.0) | |
| Between-errors 6 boxes (n) | 3.0 (0.0–6.0) | 4.0 (0.0–7.0) | 4.0 (1.0–7.0) | 4.0 (1.0–7.0) | 2.0 (0.0–7.0) | 2.0 (0.0–6.0) | |
| Between-errors 8 boxes (n) | 11.0 (4.0–15.0) | 10.0 (5.0–14.0) | 10.0 (5.0–14.0) | 11.0 (6.0–14.0) | 12.0 (8.0–14.0) | 10.0 (3.0–14.0) | |
| Strategy | 8.0 (7.0–10.0) | 8.0 (6.0–10.0) | 9.0 (7.0–10.0) | 9.0 (6.0–10.0) | 8.0 (6.0–9.0) | 9.0 (7.0–9.0) | |
Data presented as mean±sd or median (inter-quartile range) depending on the normality of the distribution. MOT: motor orientation task; PAL: paired associates learning; SST: stop-signal task; RTI: reaction time task; DMS: delayed match-to-sample; SWM: spatial working memory.