Association between study groups and the risk of all-cause mortality according to the level of systemic immune-inflammation index (SII)
| Participants n | Quartile of SII | Unadjusted model HR (95% CI) | Model 1 HR (95% CI) | Model 2# HR (95% CI) | Model 3# HR (95% CI) | |
| Ref. | 3074 211 | Low SII High SII | Ref. 1.46 (1.11–1.91) | Ref. 1.38 (1.05–1.82) | Ref. 1.33 (1.01–1.75) | Ref. 1.31 (0.99–1.73) |
| Asthma without sarcopenia | 329 21 | Low SII High SII | Ref. 1.72 (0.70–4.26) | Ref. 1.52 (0.61–3.80 | Ref. 1.44 (0.57–3.65) | Ref. 1.49 (0.59–3.78) |
| Asthma with sarcopenia | 62 13 | Low SII High SII | Ref. 1.26 (0.42–3.76) | Ref. 1.32 (0.44–3.95) | Ref. 1.21 (0.36–4.00) | Ref. 0.93 (0.26–3.28) |
| COPD without sarcopenia | 589 99 | Low SII High SII | Ref. 1.73 (1.11–2.70) | Ref. 1.66 (1.07–2.59) | Ref. 1.59 (1.02–2.48) | Ref. 1.53 (0.97–2.40) |
| COPD with sarcopenia | 92 36 | Low SII High SII | Ref. 1.58 (0.76–3.29) | Ref. 1.58 (0.76–3.29) | Ref. 1.20 (0.55–2.60) | Ref. 1.27 (0.57–2.79) |
| Sarcopenia only | 336 86 | Low SII High SII | Ref. 1.58 (1.00–2.49) | Ref. 1.60 (1.01–2.53) | Ref. 1.66 (1.05–2.63) | Ref. 1.56 (0.98–2.49) |
Bold values indicate statistical significance (p<0.05). Model 1: adjusted for sex and age (<70 years and ≥70 years); model 2: model 1 adjusted for body mass index (kg·m−2), smoking pack-years (<20 and ≥20 pack-years) and oral corticosteroid use (no use, past and current use); model 3: model 2 adjusted for the number of comorbidities. Reference (Ref.): no COPD, asthma or sarcopenia. HR: hazard ratio; low SII: sex-specific SII quartiles (1 and 2); high SII: sex-specific SII quartiles (3 and 4). #: missing values: smoking pack-years n=7 (0.2%); number of comorbidities n=186 (4.1%).