Factors associated with nonsteroidal anti-inflammatory drug-exacerbated respiratory disease (N-ERD) determined by multivariable binary logistic regression
| Crude OR (95% CI) | Adjusted# OR (95% CI) | |
| Age | ||
| 20–39 years (ref.) | ||
| 40–59 years | 2.15 (1.25–3.68) | 2.11 (1.19–3.76) |
| 60–69 years | 2.90 (1.68–4.99) | 3.08 (1.68–5.64) |
| Female sex | 1.57 (1.06–2.33) | 1.46 (0.94–2.28) |
| Family history of asthma | 2.98 (2.04–4.34) | 2.34 (1.53–3.57) |
| Family history of allergic rhinitis | 2.46 (1.68–3.59) | 2.47 (1.60–3.83) |
| Cumulative exposure¶ | ||
| 0 exposures (ref.) | ||
| 1 exposure | 1.63 (0.97–2.75) | 1.49 (0.86–2.59) |
| 2 exposures | 2.65 (1.53–4.57) | 2.41 (1.34–4.34) |
| 3 exposures | 3.83 (1.98–7.39) | 3.68 (1.82–7.46) |
| BMI | ||
| <25 kg·m−2 (ref.) | ||
| 25–29.99 kg·m−2 | 1.27 (0.82–1.98) | 1.02 (0.64–1.64) |
| ≥30 kg·m−2 | 1.72 (1.05–2.81) | 1.14 (0.67–1.95) |
| Childhood exposure to farming environment | 1.75 (1.18–2.57) | 1.38 (0.90–2.12) |
Ref.: reference category (without N-ERD); BMI: body mass index. #: adjusted to all variables in the model; ¶: cumulative exposure was classified from zero to three exposures calculating smoking (current or ex-smoking), secondhand smoke (smoke exposure at home or at work) and occupational exposure to vapours, gases, dusts and fumes.