TABLE 3

Multivariate analysis

Characteristic	Univariate			Multivariate 1 (adjusted for demographics – age, sex, WHO FC)			Multivariate 2 (adjusted for demographics and mPAP)			Multivariate 3 (adjusted for demographics, mPAP and D_LCO)
	HR	95% CI	p-value	HR	95% CI	p-value	HR	95% CI	p-value	HR	95% CI	p-value
Full cohort (n=660)
CT – centrilobular ground-glass (CGG)	0.29	0.17–0.50	<0.001	0.50	0.28–0.89	0.010	0.48	0.26–0.86	0.007	0.76	0.39–1.47	0.4
CT – ground-glass opacification (GGO)	0.53	0.38–0.74	<0.001	0.82	0.58–1.16	0.2	0.84	0.60–1.19	0.3	0.80	0.54–1.18	0.2
CT – honeycombing	2.79	1.57–4.99	<0.001	1.73	0.97–3.11	0.087	1.74	0.97–3.12	0.086	1.10	0.54–2.24	0.8
CT – emphysema	2.09	1.71–2.56	<0.001	1.48	1.21–1.83	<0.001	1.52	1.23–1.88	<0.001	1.13	0.89–1.44	0.3
CT – fibrosis	2.38	1.94–2.91	<0.001	1.75	1.42–2.15	<0.001	1.77	1.43–2.18	<0.001	1.37	1.09–1.73	0.008
IPAH (n=335)
CT – centrilobular ground-glass (CGG)	0.44	0.25–0.78	0.005	0.79	0.43–1.45	0.4	0.80	0.43–1.48	0.5	0.92	0.47–1.82	0.8
CT – ground-glass opacification (GGO)	0.52	0.32–0.86	0.010	0.88	0.52–1.47	0.6	0.91	0.54–1.52	0.7	0.96	0.55–1.69	0.9
CT – honeycombing	3.72	1.37–10.1	0.010	1.69	0.61–4.65	0.3	1.68	0.61–4.62	0.4	1.35	0.49–3.74	0.6
CT – emphysema	2.74	1.96–3.81	<0.001	1.72	1.22–2.42	0.002	1.76	1.24–2.49	0.002	1.26	0.85–1.86	0.2
CT – fibrosis	2.48	1.76–3.50	<0.001	1.42	0.99–2.02	0.060	1.44	1.00–2.07	0.056	1.23	0.84–1.81	0.3
PH-CLD (n= 325)
CT – honeycombing	2.11	1.04–4.30	0.039	1.80	0.88–3.67	0.14	2.02	0.99–4.14	0.081	1.06	0.39–2.91	>0.9
CT – fibrosis	1.83	1.42–2.35	<0.001	1.73	1.34–2.24	<0.001	1.63	1.26–2.10	<0.001	1.46	1.09–1.96	0.011

Bold text: meets statistical significance. WHO FC: World Health Organization functional class; mPAP: mean pulmonary arterial pressure; D_LCO: diffusing capacity of the lung for carbon monoxide; HR: hazard ratio; CI: confidence interval; CT: computed tomography; IPAH: idiopathic pulmonary arterial hypertension; PH-CLD: pulmonary hypertension associated with chronic lung disease.