Low-eosinophil group(<150 cells·µL^{−1}) | High-eosinophil group(≥150 cells·µL^{−1}) | Interaction HR and p-value | |

Pneumonia episodes | 1.10 (0.99–1.24) p=0.09 n=2832 | 1.05 (0.97–1.13) p=0.24 n=6321 | 0.95 (0.83–1.08) p=0.44 |

Hospitalisation due to pneumonia | 1.26 (1.05–1.50) p=0.01 n=2910 | 1.00 (0.88–1.14) p>0.99 n=6499 | 0.80 (0.64–0.99) p=0.04 |

Death due to pneumonia | 1.19 (0.50–2.84) p=0.70 n=2918 | 0.53 (0.27–1.05) p=0.07 n=6517 | 0.44 (0.65–4.42) p=0.14 |

Data are presented as hazard ratio (HR) (95% CI), unless otherwise stated. HRs are for time to first event after treatment initiation, for inhaled corticosteroid (ICS) *versus* non-ICS treatment. HRs are from Cox regression including interaction term and adjusted for covariates as detailed in figure 1.