Low-eosinophil group(<150 cells·µL^{−1}) | High-eosinophil group(≥150 cells·µL^{−1}) | Interaction HR and p-value | |

Low exacerbation rate (0 or 1) | 1.21 (1.10–1.34) p=0.001 n=2299 | 1.07 (1.00–1.15) p=0.06 n=5068 | 0.88 (0.78–0.99) p=0.04 |

Higher exacerbation rate (≥2) | 1.18 (0.97–1.44) p=0.11 n=498 | 0.94 (0.82–1.07) p=0.34 n=1102 | 0.79 (0.62–1.00) p=0.06 |

Data are presented as hazard ratio (HR) (95% CI), unless otherwise stated. HRs are for time to first exacerbation after treatment initiation, for ICS *versus* non-ICS treatment. HRs are from Cox regression including the interaction term and adjusted for covariates, as listed in figure 1. n=9007.