TABLE 4

Generalised additive model fitted to assess the association of being admitted to the intensive care unit (ICU) with 28-day fatality ratio

OR (95% CI)Estimated marginal mean (range)p-value
ICU admission0.70 (0.65–0.75)<0.0001
High-flow nasal cannula1.05 (1.00–1.11)0.052
Noninvasive respiratory support1.37 (1.31–1.44)<0.0001
Invasive mechanical ventilation1.97 (1.81–2.14)<0.0001
Vasopressors or inotropes1.56 (1.44–1.70)<0.0001
Number of comorbidities1.07 (1.06–1.09)<0.0001
Temperature on hospital admission0.92 (0.90–0.94)<0.0001
Heart rate on hospital admission1.01 (1.00–1.01)<0.0001
Respiratory rate on hospital admission1.03 (1.02–1.03)<0.0001
Systolic blood pressure on hospital admission1.00 (1.00–1.01)<0.0001
Diastolic blood pressure on hospital admission0.99 (0.99–0.99)<0.0001
Acute respiratory distress syndrome1.47 (1.39–1.56)<0.0001
Male1.25 (1.19–1.31)<0.0001
Month of hospital admission0.98 (0.96–0.99)<0.0001
New cases per million1.00 (1.00–1.00)<0.0001
Age (years)
 207.1% (5.8–8.7%)
 409.1% (8.3–9.9%)
 6019.8% (19.0–20.6%)
 8051.8% (50.7–52.9%)