TABLE 2

Treatments stratified by patients admitted to the intensive care unit (ICU)

AllPatients admitted to the ICUp-value
YesNo
Patients, n40 44020 04420 396
Invasive mechanical ventilation12 462 (30.8)11 957 (59.6)505 (2.5)<0.0001
Noninvasive mechanical ventilation15 522 (38.4)9127 (45.5)6395 (31.4)<0.0001
High-flow nasal cannula25 433 (62.9)8891 (44.4)16 542 (81.1)<0.0001
Inotropes or vasopressors16 542 (40.7)8375 (41.8)175 (0.9)<0.0001
Antibiotics35 316 (87.3)17 800 (88.8)17 516 (85.9)<0.0001
Prone positioning7825 (19.3)7390 (36.9)435 (2.1)<0.0001
Neuraminidase inhibitors231 (0.6)118 (0.6)113 (0.6)0.69
Neuromuscular blocking agents3647 (9.0)3597 (17.9)50 (0.2)<0.0001
Dialysis/haemofiltration3191 (7.9)2953 (14.7)238 (1.2)<0.0001
Corticosteroids11 435 (28.3)7627 (38.1)3808 (18.7)<0.0001
Antivirals8025 (19.8)5925 (29.6)2100 (10.3)<0.0001
Tracheostomy2461 (6.1)2422 (12.1)39 (0.2)<0.0001
ECMO706 (1.7)706 (3.5)0 (0.0)<0.0001
ACE inhibitors4399 (10.9)1991 (9.9)2408 (11.8)<0.0001
Antifungal3200 (7.9)2384 (11.9)816 (4.0)<0.0001
Angiotensin II receptor blockers2865 (7.1)1674 (8.4)1191 (5.8)<0.0001
Therapeutic anticoagulants532 (1.3)510 (2.5)22 (0.1)<0.0001
Lopinavir/ritonavir651 (1.6)397 (2.0)254 (1.2)<0.0001
Nonsteroidal anti-inflammatory2317 (5.7)1191 (5.9)1126 (5.5)0.07
Inhaled nitric oxide505 (1.2)491 (2.4)14 (0.1)<0.0001
Chloroquine/hydroxychloroquine946 (2.3)718 (3.6)228 (1.1)<0.0001
Convalescent plasma398 (1.0)248 (1.2)150 (0.7)<0.0001
Macrolides83 (0.2)66 (0.3)17 (0.1)<0.0001
Dexamethasone4174 (10.3)1992 (9.9)2182 (10.7)0.01
Interferon-β131 (0.3)118 (0.6)13 (0.1)<0.0001
Oral steroids311 (0.8)275 (1.4)36 (0.2)<0.0001
Remdesivir2009 (5.0)1092 (5.4)917 (4.5)<0.0001
IL-6 inhibitor122 (0.3)90 (0.4)32 (0.2)<0.0001
Tocilizumab51 (0.1)42 (0.2)9 (0.0)<0.0001

Data are presented as n (%), unless otherwise stated. ECMO: extracorporeal membrane oxygenation; ACE: angiotensin-converting enzyme; IL: interleukin.