TABLE 3

Patients with severe coronavirus disease 2019 who developed complications stratified by patients admitted to the intensive care unit (ICU)

AllPatients admitted to the ICUp-value
YesNo
Patients, n40 44020 04420 396
Neurological, n (%)
 Seizures393 (1.0)240 (1.2)153 (0.8)<0.0001
 Stroke489 (1.2)281 (1.4)208 (1.0)<0.0001
 Meningitis or encephalitis113 (0.3)93 (0.5)20 (0.1)<0.0001
 Other neurological complications490 (1.2)228 (1.1)262 (1.3)0.19
Cardiovascular, n (%)
 Congestive heart failure1183 (2.9)432 (2.2)751 (3.7)<0.0001
 Endocarditis, myocarditis, pericarditis223 (0.6)191 (1.0)32 (0.2)<0.0001
 Cardiac arrhythmia2992 (7.4)1995 (10.0)997 (4.9)<0.0001
 Cardiac arrest1457 (3.6)1012 (5.0)445 (2.2)<0.0001
 Cardiac ischaemia556 (1.4)303 (1.5)253 (1.2)0.021
 Cardiomyopathy195 (0.5)138 (0.7)57 (0.3)<0.0001
 Myocardial infarction34 (0.1)31 (0.2)3 (0.0)<0.0001
Pulmonary, n (%)
 Bacterial pneumonia4695 (11.6)2591 (12.9)2104 (10.3)<0.0001
 Acute respiratory distress syndrome7928 (19.6)5747 (28.7)2181 (10.7)<0.0001
 Pneumothorax555 (1.4)447 (2.2)108 (0.5)<0.0001
 Pleural effusion2198 (5.4)1093 (5.5)1105 (5.4)0.89
 Pulmonary embolism272 (0.7)237 (1.2)35 (0.2)<0.0001
 Cryptogenic organising pneumonia122 (0.3)95 (0.5)27 (0.1)<0.0001
Gastrointestinal, n (%)
 Pancreatitis138 (0.3)103 (0.5)35 (0.2)<0.0001
 Liver dysfunction2385 (5.9)1703 (8.5)682 (3.3)<0.0001
 Gastrointestinal haemorrhage393 (1.0)221 (1.1)172 (0.8)0.008
Renal, n (%)
 Acute kidney injury6566 (16.2)4030 (20.1)2536 (12.4)<0.0001
Metabolic, n (%)
 Hyperglycaemia3232 (8.0)2265 (11.3)967 (4.7)<0.0001
 Hypoglycaemia757 (1.9)355 (1.8)402 (2.0)0.14
Haematological, n (%)
 Anaemia5057 (12.5)3203 (16.0)1854 (9.1)<0.0001
 Disseminated intravascular coagulation1296 (3.2)844 (4.2)452 (2.2)<0.0001
 Bleeding84 (0.2)80 (0.4)4 (0.0)<0.0001
Others, n (%)
 Other complication6321 (15.6)2883 (14.4)3438 (16.9)<0.0001
 Bacteraemia1848 (4.6)1366 (6.8)482 (2.4)<0.0001
 Rhabdomyolysis or myositis246 (0.6)185 (0.9)61 (0.3)<0.0001