TABLE 1

Distribution of treatment outcome among childhood extensively drug-resistant tuberculosis patients (N=42)

CharacteristicsTreatment outcomep-value
SuccessfulUnsuccessful
Age0.537
 <10 years9 (45%)11 (55%)
 10–14 years12 (54.5%)10 (45.5%)
Baseline weight0.525
 ≤35 kg7 (43.8%)9 (56.2%)
 >35 kg14 (53.8%)12 (46.2%)
Sex0.495
 Female14 (46.7%)16 (53.3%)
 Male7 (58.3%)5 (41.7%)
History of TB treatment0.726
 No5 (45.5%)6 (54.5%)
 Yes16 (51.6%)15 (48.4%)
History of use of SLD0.095
 No17 (58.6%)12 (41.4%)
 Yes4 (30.8%)9 (69.2%)
History of MDR-TB treatment0.079
 No18 (58.1%)13 (41.9%)
 Yes3 (27.3%)8 (72.7%)
Comorbidities1.000
 No21 (52.5%)19 (47.5%)
 Yes0 (0.0%)2 (100%)
Baseline sputum smear gradingNot measured
 Negative3 (37.5%)5 (62.5%)
 Scanty#1 (100%)0 (0.0%)
 +111 (64.7%)6 (35.3%)
 +2+1 (16.7%)5 (83.3%)
 +3§5 (50%)5 (50%)
Sputum culture conversion0.976
<2 months13 (72.2%)5 (27.8%)
 >2 months8 (72.7%)3 (27.3%)
Use of linezolid0.726
 No5 (45.5%)6 (54.6%)
 Yes16 (51.6%)15 (48.4%)
Use of clofazimine0.064
 No14 (63.6%)8 (36.4%)
 Yes7 (35%)13 (65%)
Use of bedaquiline0.634
 No18 (48.6%)19 (51.4%)
 Yes3 (60%)2 (40%)

TB: tuberculosis; SLD: second-line drug; MDR: multidrug-resistant. #: 1–9 acid-fast bacilli (AFB) per 100 high-power fields (HPFs); : 10–99 AFB per 100 HPFs; +: 1–9 AFB per HPF; §: >9 AFB per HPF.