Outcome definitions for acute exacerbation, arrhythmia, myocardial infarction, hip fracture, opportunistic infection and sensorineural hearing loss
| Outcome | Algorithm/ICD-9-CM principal diagnostic codes | Reference |
| Arrhythmia | ICD-9-CM 427.x (principal diagnosis) | Tamariz 2012 [44] |
| Myocardial infarction | ICD-9-CM 410.x1 | Kiyota 2004 [45] |
| Hip fracture | ICD-9-CM 820.0x or 820.20 or 820.21 or 820.22 or 820.8 or 821.0x | Narongroeknawin 2012 [46] |
| Opportunistic infection | Any of the following diagnoses: | |
| Tuberculosis | ICD-9-CM 010-018 and pharmacy records indicating prescription for pyrazinamide prescribed on same day within ±90 days of first code date | Schneeweiss 2007 [47] |
| Histoplasmosis | ICD-9-CM 115 with cumulative supply of >30 days of any of the following three drugs: fluconazole, itraconazole or voriconazole given within ±90 days of first code date | Schneeweiss 2007 [47] |
| Blastomycosis | ICD-9-CM 116.0 with cumulative supply of >30 days of any of the following three drugs: fluconazole, itraconazole or voriconazole given within ±90 days of first code date | Schneeweiss 2007 [47] |
| Coccidioidomycosis | ICD-9-CM 114 with cumulative supply of >30 days of any of the following three drugs: fluconazole, itraconazole or voriconazole given within ±90 days of first code date | Schneeweiss 2007 [47] |
| Cryptococcosis | ICD-9-CM 117.5 with cumulative supply of >30 days of any of the following three drugs: fluconazole, itraconazole or voriconazole given within ±90 days of first code date | Schneeweiss 2007 [47] |
| Endemic mycosis (nonspecific outcome of all endemic fungi above) | ICD-9-CM 484.7 with cumulative supply of >30 days of any of the following three drugs: fluconazole, itraconazole or voriconazole given within ±90 days of first code date | Schneeweiss 2007 [47] |
| Nocardiosis/actinomycosis | ICD-9-CM 039 | Schneeweiss 2007 [47] |
| Listeriosis | ICD-9-CM 027.0 | Schneeweiss 2007 [47] |
| Toxoplasmosis | ICD-9-CM 130 | Schneeweiss 2007 [47] |
| Pneumocystis | ICD-9-CM 136.3 | Schneeweiss 2007 [47] |
| Legionellosis | ICD-9-CM 482.84 | Schneeweiss 2007 [47] |
| Salmonellosis | ICD-9-CM 003.1, 003.2x | Schneeweiss 2007 [47] |
| Aspergillosis | ICD-9-CM 117.3 or 484.6 with any outpatient prescription for voriconazole, itraconazole, posaconazole given within ±90 days of first code date | Schneeweiss 2007 [47] Baddley 2014 [36] |
| Zoster | ICD-9-CM 053 (outpatient or inpatient code) with any outpatient prescription for acyclovir, famciclovir or valacyclovir given within ±90 days of first code date | Jumaan 2005 [48] Mullooly 2005 [49] |
| Sensorineural hearing loss | ICD-9-CM 389.10 or 389.11 or 389.12 or 389.14 or 389.18 or 389.20 or 389.22 | Not validated |
ICD-9-CM: International Classification of Diseases, Ninth Revision, Clinical Modification.