Purchase costs and import costs of longer and shorter tuberculosis (TB) drug regimens for a TB programme in Karakalpakstan, Uzbekistan
| TB drug regimen used for treatment (scenario) | Tablets and injections per regimen | Import weight per regimen kg | Drug cost per regimen USD | Import cost per regimen USD | Import cost (% of drug cost) |
| Drug-susceptible TB treatment | |||||
| 2 HRZE/4 HR (reference scenario 1) | 730 | 0.79 | 43 | 4.17 | 9.8 |
| 2 Rpt-H-Z-Mfx/2 Rpt-H-Mfx (scenario 2) | 1358 | 1.1 | 233 | 6.04 | 2.6 |
| Multidrug-resistant TB treatment | |||||
| 20 Bdq-Lfx-Lzd-Cfz-Cs (reference scenario 1) | 4824 | 7.8 | 1977 | 41 | 2.1 |
| 4 Km-Mfx-Pto-Cfz-Z-Hh-E/5 Z-E-Mfx-Pto-Cfz (scenario 2) | 3650 | 7.6 | 393 | 40 | 10.3 |
| 6 Bdq-Pa-Lzd (scenario 3) | 748 | 0.84 | 855 | 4.45 | 0.52 |
| 8 Z-Km-Lfx-PAS-Pto-Cs/12 Z-Lfx-PAS-Pto-Cs (scenario 4) | 9368 | 27 | 2442 | 144 | 5.9 |
Months and drugs for intensive phase/continuation phase of treatment. The exact duration of the 2 Rpt-H-Z-Mfx/2 Rpt-H-Mfx regimen is 8 weeks/9 weeks. The TB drug regimens included in the model represent the least costly regimens and lowest treatment durations from a larger set of DS-TB and MDR-TB drug regimens described in supplementary table S2. HRZE/HR: fixed-dose combination of four/two oral antibiotics; 2 Rpt-H-Z-Mfx: 2 months of single doses of the antibiotics Rpt, H, Z and Mfx; Bdq: bedaquiline 100 mg; Cs: cycloserine 250 mg; Cfz: clofazimine 100 mg; E: ethambutol 400 mg; H: isoniazid 300 mg; Hh: high-dose isoniazid 600 mg; Km: kanamycin 1000 mg (injectable antibiotic); Lfx: levofloxacin 250 mg; Lzd: linezolid 600 mg; Mfx: moxifloxacin 400 mg; Pa: pretomanid 200 mg; PAS: PAS sodium 4 g; Pto: prothionamide 250 mg; R: rifampicin 300 mg; Rpt: rifapentine 150 mg; Z: pyrazinamide 400 mg. Data sources: Kohler et al. [21, 31].