Drug regimens used for drug-susceptible and multidrug-resistant TB treatment (combination) | Total procurement cost USD K (±sd) | Drug cost USD K (±sd) | Import cost USD K (±sd) |
6-month and 20-month all-oral (reference combination) | 1435±280 | 1401±274 | 34±6.4 |
6-month and 9-month including an injectable antibiotic (least costly combination) | 365±68 | 331±62 | 34±6.3 |
Δ to reference combination | −1070±129*** | −1070±125*** | −0.54±4.0 |
Δ to reference combination (%) | −75±0.31*** | −76±0.30*** | −1.6±0.025*** |
4-month and 20-month all-oral (costliest combination) | 1730±322 | 1692±315 | 37±6.8 |
Δ to reference combination | 294±191 | 291±187 | 2.9±4.2 |
Δ to reference combination (%) | 21±1.6*** | 21±1.6*** | 8.4±0.57*** |
4-month and 6-month all-oral (shortest combination) | 947±168 | 934±166 | 12±2.0 |
Δ to reference combination | −489±146* | −467±143* | −22±3.0*** |
Δ to reference combination (%) | −34±1.8*** | −33±1.9*** | −64±1.7*** |
6-month and 20-month including an injectable antibiotic (phased-out combination) | 1819±356 | 1715±336 | 104±20 |
Δ to reference combination | 383±203 | 314±194 | 70±9.5*** |
Δ to reference combination (%) | 27±0.11*** | 22±0.087*** | 203±3.2*** |
Cost range | 365–1730 [1819] | 331–1692 [1715] | 12–37 [104] |
The TB drugs and dosing of the regimens are described in table 1. A breakdown of the import costs into air freight, land freight and customs-related costs is provided in supplementary table S3. K: thousand; Δ difference. [ ]: no longer recommended drug regimen. *: p<0.05; **: p<0.01; ***: p<0.001.