TABLE 6

Longitudinal analyses of cannabis and tobacco use between ages 38 and 45 years with pre-bronchodilator impulse oscillometry (IOS) measures stratified by sex

R5R20R5R20X5AXfres
Women
 Participants (n)426426426425422423
 Joint-years 38–45 years
  β (95% CI)0.125 (0.035–0.214)0.075 (−0.025–0.176)0.085 (−0.019–0.189)0.125 (0.035–0.218)0.140 (0.054–0.226)0.129 (0.042–0.217)
  p-value0.0060.1420.1090.0080.0010.004
 Pack-years 38–45 years
  β (95% CI)0.002 (−0.107–0.111)−0.007 (−0.129–0.115)0.077 (−0.049–0.203)−0.064 (−0.176–0.047)−0.017 (−0.121–0.087)0.013 (−0.093–0.120)
  p-value0.9720.9060.2320.2580.7490.804
Men
 Participants (n)438438438437434434
 Joint-years 38–45 years
  β (95% CI)0.049 (−0.019–0.117)0.049 (−0.029–0.127)0.015 (−0.047–0.077)0.023 (−0.045–0.091)0.039 (−0.028–0.107)0.066 (−0.003–0.135)
  p-value0.1580.2140.6440.5100.2550.062
 Pack-years 38–45 years
  β (95% CI)0.025 (−0.038–0.088)<0.001 (−0.073–0.073)0.034 (−0.023–0.091)0.093 (0.029–0.157)0.060 (−0.003–0.122)0.017 (−0.047–0.081)
  p-value0.4320.9990.2420.0050.0630.601

All IOS measures are log-transformed and analyses are adjusted for use of both substances and also adjusted for body mass index, height and the relevant IOS measure at age 38 years (e.g. resistance at 5 Hz (R5) at 38 years is the adjustment for age 45 years R5); statistically significant associations are bolded. β-values are standardised regression coefficients, which represent the standard deviation difference in IOS measure associated with each standard deviation change in joint- or pack-years. R20: resistance at 20 Hz; R5R20: difference between R5 and R20; X5: reactance at 5 Hz; AX: area under the reactance curve between 5 Hz and resonant frequency (fres).