TABLE 6

Primary and secondary multivariate analyses

OutcomeEvents/person-monthsEvents/person-monthsMultivariate IRR (95% CI)
Serious adverse eventsStandard treatment with bedaquiline#Prolonged treatment with bedaquiline
 Up to 5 months after bedaquiline cessation38/76718/4050.82 (0.42–1.61)
 Within the first 190 days of treatment33/41010/1870.73 (0.33–1.61)
Serious adverse eventsWithin the first 190 days of treatmentFrom day 190 until 5 months after bedaquiline cessation
 Among persons receiving prolonged treatment10/1878/2120.75 (0.30–1.88)

#: reference group.