TABLE 3

Associations between different genotypes of sulfatase modifying factor (SUMF1) single nucleotide polymorphisms and forced expiratory volume in 1 s (FEV₁), forced vital capacity (FVC) and FEV₁/FVC ratio in the total study population including both COPD and control subjects

	ref/ref	ref/var	FEV₁	FVC	FEV₁/FVC
	ref/ref	var/var	FEV₁	FVC	FEV₁/FVC
rs4685744	CC	CT	0.82	0.030 B= −0.12	0.093 B=0.024
		TT	0.81	0.037 B= −0.14	0.27
rs2819562	CC	CT	0.79	0.048 B= −0.12	0.076 B=0.027
		TT	0.73	0.057 B= −0.13	0.074 B=0.030
rs2819561	AA	AG	0.76	0.050 B= −0.12	0.073 B=0.0028
		GG	0.71	0.060 B= −0.12	0.076 B=0.029
rs2633852	AA	AG	0.72	0.062 B= −0.12	0.075 B=0.028
		GG	0.67	0.071 B= −0.12	0.073 B=0.030
rs11915920	CC	CT	0.98	0.021 B= −0.13	0.15
		TT	0.84	0.031 B= −0.14	0.23
rs807785	CC	CT	0.87	0.64	0.61
		TT	0.41	0.87	0.16
rs3864051	CC	CT	0.48	0.14	0.67
		TT	<0.001 B= −0.64	0.31	<0.001 B= −0.20
rs794187	CC	CT	0.028 B=0.12	0.062 B=0.094	0.22
		TT	0.72	0.62	0.98
rs794185	TT	TC	0.002 B=0.18	0.004 B=0.16	0.11
		CC	0.033 B=0.16	0.057 B=0.13	0.32
rs2322683	CC	CT	0.17	0.25	0.41
		TT	0.87	0.57	0.82
rs793391	TT	TG	0.024 B=0.12	0.42	0.039 B=0.026
		GG	0.66	0.65	0.79
rs12634249	CC	CA	0.039 B=0.11	0.30	0.060 B=0.024
		AA	0.12	0.89	0.077 B= −0.045
rs2819590	CC	CT	0.010 B=0.14	0.36	0.016 B=0.030
		TT	0.76	0.74	0.42
rs304092	GG	GA	0.025 B=0.12	0.44	0.037 B=0.026
		AA	0.99	0.53	0.39

Data are presented as p-values from linear regression between the reference allele (ref)/ref and ref/variance allele (var) or var/var (using ref/ref as reference genotype) as indicated, and adjusted for age, sex, height and smoking status. B-value is the unstandardised β-value, and is presented when p<0.1. Significant associations are depicted in bold.