Risk factors for mortality within the first year after discharge in PAH patients admitted to the ICU
| Unadjusted HR (95% CI) | p-value | Adjusted for PAH diagnosis and age HR (95% CI) | p-value | |
| Age per year | 1.02 (1.01–1.04) | 0.01 | NA | NA |
| Female versus male | 0.89 (0.49–1.62) | 0.70 | 0.98 (0.53–1.81) | 0.93 |
| CTD-PAH versus IPAH | 2.31 (1.28–4.16) | 0.005 | 1.89 (1.01–3.59)# | 0.05 |
| WHO FC pre-admission (III and IV) | 3.24 (0.95–11.02) | 0.06 | 2.99 (0.84–10.63) | 0.09 |
| Charlson index ≥2 | 4.41 (0.53–36.67) | 0.17 | 1.25 (0.35–4.52) | 0.72 |
| Data on admission | ||||
| Systolic BP <100 mmHg | 1.08 (0.70–1.68) | 0.72 | 1.06 (0.69–1.64) | 0.78 |
| Anaemia | 0.91 (0.55–1.49) | 0.70 | 0.86 (0.53–1.40) | 0.55 |
| eGFR <60 mL·min−1 per 1.73 m2 | 1.91 (0.76–4.78) | 0.16 | 1.52 (0.59–3.92) | 0.38 |
| Na <136 mEq·mL−1 | 1.87 (1.21–2.89) | 0.005 | 1.71 (1.08–2.69) | 0.021 |
| ProBNP pg·mL−1 (log transformed) | 1.48 (1.10–1.98) | 0.009 | 1.35 (1.01–1.83) | 0.04 |
| Bilirubin, total, mg·dL−1 | 1.12 (1.00–1.26) | 0.06 | 1.19 (1.05–1.34) | 0.006 |
| In-hospital support | ||||
| Need for vasopressors/inotropes | 2.73 (1.73–4.30) | <0.001 | 2.57 (1.62–4.08) | <0.001 |
| Need for mechanical ventilation | 2.05 (1.24–3.38) | 0.005 | 2.06 (1.25–3.40) | 0.005 |
| Need for renal replacement therapy | 1.80 (0.68–4.76) | 0.23 | 1.91 (0.68–5.38) | 0.21 |
PAH: pulmonary arterial hypertension; ICU: intensive care unit; CTD-PAH: connective tissue diseases PAH; IPAH: idiopathic PAH; WHO FC: World Health Organization functional class; BP: blood pressure; eGFR: estimated glomerular filtration rate; Na: sodium; proBNP: pro-B-type natriuretic peptide. #: adjusted only for age.