TABLE 5

Associations between different genotypes of sulfatase modifying factor (SUMF1) single nucleotide polymorphisms and airway resistance and reactance measured by impulse oscillometry in the total study population including both COPD and control subjects

	ref/ref	ref/var	R₅	R₂₀	R₅–R₂₀	X₅	AX
	ref/ref	var/var	R₅	R₂₀	R₅–R₂₀	X₅	AX
rs4685744	CC	CT	0.56	0.35	0.82	0.83	0.72
		TT	0.32	0.46	0.44	0.64	0.95
rs2819562	CC	CT	0.32	0.41	0.28	0.52	0.21
		TT	0.69	0.82	0.80	0.95	0.61
rs2819561	AA	AG	0.31	0.41	0.27	0.50	0.20
		GG	0.67	0.85	0.74	0.94	0.63
rs2633852	AA	AG	0.27	0.33	0.26	0.48	0.19
		GG	0.83	0.99	0.86	0.97	0.55
rs11915920	CC	CT	0.61	0.36	0.89	0.70	0.85
		TT	0.33	0.52	0.39	0.65	0.92
rs807785	CC	CT	0.45	0.85	0.14	0.13	0.22
		TT	0.49	0.76	0.15	0.095 B=0.022	0.26
rs3864051	CC	CT	0.29	0.45	0.39	0.21	0.36
		TT	0.032 B=0.079	0.43	0.003 B=0.062	0.005 B= −0.067	0.009 B=0.61
rs794187	CC	CT	0.086 B= −0.020	0.72	0.013 B= −0.017	0.018 B=0.018	0.015 B= −0.18
		TT	0.79	0.93	0.56	0.91	0.79
rs794185	TT	TC	0.002 B= −0.039	0.14	<0.001 B= −0.026	<0.001 B=0.030	<0.001 B= −0.30
		CC	0.030 B= −0.035	0.39	0.004 B= −0.026	0.031 B=0.023	0.020 B= −0.24
rs2322683	CC	CT	0.21	0.33	0.27	0.11	0.11
		TT	0.62	0.89	0.48	0.89	0.81
rs793391	TT	TG	0.014 B= −0.029	0.16	0.007 B= −0.018	0.012 B=0.019	0.008 B= −0.20
		GG	0.60	0.71	0.61	0.96	1.00
rs12634249	CC	CA	0.13	0.68	0.029 B= −0.014	0.024 B=0.017	0.028 B= −0.16
		AA	0.39	0.87	0.30	0.59	0.48
rs2819590	CC	CT	0.010 B= −0.030	0.048 B= −0.014	0.021 B= −0.015	0.025 B=0.17	0.011 B= −0.19
		TT	0.85	0.92	0.84	0.65	0.71
rs304092	GG	GA	0.010 B= −0.030	0.053 B= −0.014	0.018 B= −0.016	0.029 B=0.017	0.022 B= −0.17
		AA	0.81	0.78	0.92	0.69	0.66

Data are presented as p-values from linear regression between the reference allele (ref)/ref and ref/variance allele (var) or var/var, adjusted for age, sex, height and smoking status. B-value is the unstandardised β-value and is shown when p<0.1. Significant associations are depicted in bold. R₅: resistance at 5 Hz; R₂₀: resistance at 20 Hz; X₅: reactance at 5 Hz; AX: reactance area.