TABLE 3

Test characteristics of CPET parameters for residual PH

ParameterSensitivitySpecificityPPVFalse-positive ratePositive LRNPVFalse-negative rateNegative LRNumber-needed-to-catheterise
Peak load <80% predicted28/34 (0.82)25/54 (0.46)28/57 (0.49)29/57 (0.51)1.5325/31 (0.81)6/31 (0.19)0.3857/88 (0.65)
Peak VO2 <80% predicted29/34 (0.85)26/54 (0.48)29/57 (0.51)28/57 (0.49)1.6426/31 (0.84)5/31 (0.16)0.3157/88 (0.65)
VO2/WR <8.4 mL·min−1·W−123/31 (0.74)42/51 (0.82)23/32 (0.72)9/32 (0.28)4.2042/50 (0.84)8/50 (0.16)0.3132/82 (0.39)
O2 pulse <80% predicted17/34 (0.50)41/54 (0.76)17/30 (0.57)13/30 (0.43)2.0841/58 (0.71)17/58 (0.29)0.6630/88 (0.34)
PETCO2 peak exercise <4.0 kPa22/34 (0.65)32/54 (0.59)22/44 (0.50)22/44 (0.50)1.5932/44 (0.73)12/44 (0.27)0.6044/88 (0.50)
VE/VCO2 AT ≥3422/32 (0.69)37/54 (0.69)22/39 (0.56)17/39 (0.44)2.1837/47 (0.79)10/47 (0.21)0.4639/86 (0.45)

AT: anaerobic threshold; CPET: cardiopulmonary exercise testing; LR: likelihood ratio; NPV: negative predictive value; PETCO2: end-tidal carbon dioxide partial pressure; PH: pulmonary hypertension; PPV: positive predictive value; VE/VCO2: ventilatory equivalent for carbon dioxide; VO2: oxygen consumption; WR: work rate.