TABLE 4

Associations between different genotypes of sulfatase modifying factor (SUMF1) single nucleotide polymorphisms and diffusing capacity and lung volumes in the total study population including both COPD and control subjects

	ref/ref	ref/var	D_LCO	V_A	D_LCO/V_A	RV	TLC
	ref/ref	var/var	D_LCO	V_A	D_LCO/V_A	RV	TLC
rs4685744	CC	CT	0.26	0.23	0.080 B=0.048	0.46	0.088 B= −0.14
		TT	0.14	0.006 B= −0.22	0.0 B=0.11	0.068 B=−0,15	0.009 B= −0.25
rs2819562	CC	CT	0.12	0.41	0.023 B=0.067	0.49	0.13
		TT	0.041 B=0.38	0.083 B= −0.14	<0.001 B=0.11	0.068 B=−0.15	0.024 B= −0.22
rs2819561	AA	AG	0.12	0.41	0.023 B=0.067	0.47	0.12
		GG	0.036 B=0.39	0.090 B= −0.14	<0.001 B=0.11	0.069 B=−0.15	0.027 B= −0.21
rs2633852	AA	AG	0.12	0.40	0.022 B=0.068	0.41	0.11
		GG	0.044 B=0.38	0.099 B= −0.14	0.001 B=0.11	0.062 B= −0.15	0.025 B= −0.22
rs11915920	CC	CT	0.37	0.19	0.12	0.56	0.10 B= −0.14
		TT	0.11	0.010 B= −0.21	<0.001 B=0.11	0.059 B= −0.15	0.012 B= −0.24
rs807785	CC	CT	0.91	0.38	0.75	0.26	0.062 B= −0.24
		TT	0.72	0.87	0.67	0.18	0.23
rs3864051	CC	CT	0.12	0.057 B=0.11	0.70	0.56	0.063 B=0.13
		TT	0.029 B= −1.01	0.49	0.080 B= −0.14	0.16	0.29
rs794187	CC	CT	0.15	0.030 B=0.13	0.81	0.67	0.69
		TT	0.67	0.94	0.64	0.80	0.91
rs794185	TT	TC	0.091 B=0.26	0.001 B=0.22	0.86	0.32	0.36
		CC	0.14	0.29	0.33	0.37	0.76
rs2322683	CC	CT	0.96	0.061 B=0.17	0.35	0.66	0.22
		TT	0.82	0.50	0.49	0.91	0.26
rs793391	TT	TG	0.34	0.064 B=0.11	0.86	0.44	0.92
		GG	0.70	0.64	0.91	0.51	0.50
rs12634249	CC	CA	0.84	0.58	0.92	0.022 B= −0.14	0.29
		AA	0.18	0.73	0.25	0.27	0.81
rs2819590	CC	CT	0.32	0.078 B=0.11	0.73	0.28	0.54
		TT	0.45	0.91	0.39	0.16	0.52
rs304092	GG	GA	0.43	0.095 B=0.10	0.89	0.45	0.48
		AA	0.78	0.71	0.52	0.28	0.60

Data are presented as p-values from linear regression between the reference allele (ref)/ref and ref/variance allele (var) or var/var as indicated, and adjusted for age, sex, height and smoking status. B-value is the unstandardised β-value, and is shown when p<0.1. Significant associations are depicted in bold. D_LCO: diffusing capacity of the lung for carbon monoxide; V_A: alveolar volume; RV: residual volume; TLC: total lung capacity.