Number of tests and days to the first diagnostic test after pulmonary endarterectomy (PEA) in the overall population, and in the post hoc defined pre-riociguat approval and post-riociguat approval subgroups
| Total population# | Pre-riociguat approval¶ | Post-riociguat approval+,§ | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Diagnostic test | n (%) | Number of tests after PEA | Number of days to first test | n (%) | Number of tests after PEA | Number of days to first test | n (%) | Number of tests after PEA | Number of days to first test |
| Any test | 92 (89) | 4.6±3.8 | 182.7±100.4 | 48 (87) | 3.8±2.3 | 196.9±117.8 | 44 (92) | 5.4±4.8 | 167.3±75.6 |
| Echo | 87 (84) | 2.4±1.2 | 221.7±128.1 | 47 (85) | 2.4±1.2 | 222.6±122.1 | 40 (83) | 2.4±1.2 | 220.7±136.4 |
| 6MWD | 35 (34) | 2.9±1.5 | 221.4±147.5 | 13 (24) | 2.8±1.7 | 174.2±101.4 | 22 (46) | 2.9±1.4 | 249.4±164.8 |
| CTA | 33 (32) | 1.8±1.9 | 242.3±159.2 | 17 (31) | 2.2±2.6 | 223.9±127.7 | 16 (33) | 1.4±0.7 | 261.9±189.5 |
| NT-proBNP | 33 (32) | 3.4±3.9 | 236.2±145.3 | 13 (24) | 1.8±1.3 | 283.7±185.1 | 20 (42) | 4.5±4.7 | 205.4±106.7 |
| V′/Q′ scan | 29 (28) | 1.5±0.7 | 291.8±185.9 | 10 (18) | 1.6±0.5 | 287.0±202.6 | 19 (40) | 1.4±0.8 | 294.4±182.3 |
| PAG | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| RHC | 5 (5) | 2.4±2.6 | 410.0±248.6 | 1 (2) | 1.0±NA | 133.0±NA | 4 (8) | 2.8±2.9 | 479.3±224.5 |
Data are presented as mean±sd, unless indicated otherwise. 6MWD: 6-min walk distance; CTA: computed tomography angiogram; Echo: echocardiogram; NA: not available; NT-proBNP: N-terminal prohormone of brain natriuretic protein; PAG: pulmonary angiogram; RHC: right heart catheterisation; V′/Q′: ventilation/perfusion. #: n=103; ¶: n=55; +: post hoc analysis including the 21 patients whose post-PEA observation period overlapped with the period following riociguat approval in the USA; §: n=48.