Current role of antifibrotic drugs in lung cancer and fibrosing interstitial lung diseases (fILD)

StatementCurrent status
Improves outcomes by improving fILD outcomesDefinite effect
May improve outcomes by protecting against acute exacerbation with lung cancer treatments:
 Cancer resectionProof of concept
 ChemotherapyAttractive hypothesis
May have worthwhile standalone antitumour effects:
In vitro and animal dataAttractive hypothesis
 Reduced occurrence of cancer in pirfenidone-treated patientsProof of concept?
 Antitumour effects in NSCLC with nintedanibProof of concept?
May also increase the incidence of lung cancer/fILD due to prolonged survivalAttractive hypothesis

NSCLC: nonsmall cell lung cancer.