TABLE 2

Single nucleotide polymorphisms (SNPs) associated with bronchodilator response in six independent cohort meta-analyses with p<5×10⁻⁶ after linkage disequilibrium-clumping in the ancestry-stratified meta-analysis and the combined meta-analysis

Anc/Phe^#	SNP	Chr:position^¶	Allele	AF⁺	Effect	se	p-value	Closest gene	Distance^§
Ancestry-stratified meta-analysis
EA	rs13262811	8:142425325	A	0.85	0.81	0.17	1.8E-06	PTP4A3	6162
FEV₁	rs140005306	2:143707656	A	0.95	1.25	0.26	2.0E-06	KYNU	within
	rs7315471	12:13333283	A	0.07	1.14	0.24	2.1E-06	EMP1	16318
	rs10220877	15:38934425	A	0.17	0.73	0.16	3.2E-06	C15orf53	54373
	rs76890972	16:84399755	A	0.09	1	0.22	4.7E-06	ATP2C2	2373
	rs72766398	2:12489567	T	0.95	1.31	0.28	3.6E-06	MIR3681HG	within
	rs8014708	14:101214590	A	0.1	−0.94	0.2	3.8E-06	DLK1	10029
EA FVC	rs7096465	10:4250500	T	0.09	0.98	0.20	1.1E-06	LINC00702	within
	rs10894263	11:130699110	A	0.56	0.58	0.12	8.1E-07	LOC100507431	14977
	rs8046017	16:84378488	A	0.57	−0.56	0.12	4.3E-06	WFDC1	15031
	rs10020466	4:181306647	A	0.71	0.59	0.13	3.8E-06	LINC00290	678595
	rs989808	4:47166781	T	0.16	0.73	0.16	2.6E-06	GABRB1	within
AA	rs116556600	21:15154158	A	0.43	−1.26	0.25	5.8E-07	MIR8069-1	57563
FEV₁	rs11130868	3:6249417	C	0.6	1.2	0.24	9.8E-07	GRM7-AS3	424627
	rs35870000	9:14801710	A	0.12	−1.72	0.37	3.4E-06	FREM1	within
	rs2532841	10:119069842	A	0.66	1.16	0.25	4.8E-06	PDZD8	within
	rs4852100	2:240571827	A	0.76	−1.34	0.29	4.9E-06	LOC150935	112726
	rs58795512	2:40312398	A	0.94	−2.54	0.53	1.6E-06	SLC8A1-AS1	within
	rs491175	2:45151690	C	0.6	1.26	0.24	2.4E-07	SIX3-AS1	15602
	rs186201422	10:133458567	T	0.063	−2.85	0.62	3.7E-06	N/A	N/A
	rs144465006	11:18273453	A	0.077	−2.35	0.51	3.5E-06	N/A	N/A
	rs10426116	19:44591553	T	0.059	2.55	0.52	1.1E-06	ZNF284	within
AA FVC	rs2400730	3:135796524	A	0.29	1.53	0.29	1.6E-07	PPP2R3A	within
	rs10495859	2:36241146	T	0.82	−1.77	0.34	2.0E-07	LOC100288911	340745
	rs12406488	1:88071848	A	0.87	−1.8	0.39	3.7E-06	LINC01364	234510
	rs11680558	2:11522391	A	0.086	2.68	0.56	1.4E-06	LINC00570	11715
	rs41265547	2:189872891	C	0.21	1.51	0.32	1.9E-06	COL3A1	within
	rs6864533	5:20534743	T	0.093	2.43	0.48	3.3E-07	CDH18	within
	rs1736601	6:167683260	T	0.64	1.24	0.27	3.5E-06	UNC93A	21542
	rs7336381	13:114963436	A	0.77	−1.42	0.31	3.4E-06	CDC16	36925
	rs80202087	15:78653983	A	0.095	−2.12	0.46	4.7E-06	CRABP1	13411
	rs1974858	16:26743681	A	0.42	−1.23	0.26	2.8E-06	C16orf82	334537
	rs3935851	8:31133902	T	0.1	2.41	0.52	3.1E-06	WRN	102625
	rs13437873	7:48189850	A	0.74	1.36	0.29	2.8E-06	ABCA13	21206
	rs2217516	8:94401023	A	0.57	1.24	0.26	1.6E-06	LINC00535	within
	rs12713765	2:72023225	A	0.59	1.27	0.25	6.4E-07	DYSF	109332
	rs113520112	2:110362336	C	0.093	2.24	0.44	3.5E-07	SEPT10	within
	rs74491400	2:224088691	T	0.062	2.49	0.53	2.4E-06	KCNE4	168334
	rs28672350	4:24166929	A	0.88	1.89	0.4	2.6E-06	PPARGC1A	275229
	rs55699229	8:19114322	T	0.9	−2.25	0.47	1.7E-06	LOC100128993	11290
	rs144212455	15:53363818	C	0.94	−2.59	0.54	1.9E-06	ONECUT1	281609
	rs199964754	18:63446314	T	0.51	1.42	0.3	2.4E-06	CDH7	within
Combined meta-analysis
FEV₁	rs1953833	1:239941671	A	0.71	−0.54	0.12	3.6E-06	CHRM3	within
	rs140005306	2:143707656	A	0.95	1.20	0.26	3.0E-06	KYNU	within
	rs6780151	3:6249820	A	0.60	1.26	0.26	1.2E-06	N/A	N/A
	rs9868510	3:105700120	A	0.51	−0.52	0.11	2.1E-06	CBLB	112233
	rs9385215	6:122074667	A	0.10	−0.88	0.19	2.7E-06	GJA1	303777
	rs13262811	8:142425325	A	0.86	0.76	0.16	2.2E-06	PTP4A3	6162
	rs7079679	10:102055546	A	0.53	0.50	0.11	3.0E-06	PKD2L1	within
	rs186201422	10:133458567	T	0.06	−2.85	0.62	3.7E-06	N/A	N/A
	rs144465006	11:18273453	A	0.08	−2.35	0.51	3.5E-06	N/A	N/A
	rs11055267	12:13329855	A	0.93	−1.14	0.23	1.1E-06	EMP1	19746
	rs4782614	16:84396105	A	0.32	0.64	0.12	7.5E-08	ATP2C2	6023
	rs76890972	16:84399755	A	0.08	1.02	0.21	1.6E-06	ATP2C2	2373
	rs10426116	19:44591553	T	0.06	2.56	0.52	1.1E-06	ZNF284	within
FVC	rs113520112	2:110362336	C	0.09	2.24	0.44	3.6E-07	SEPT10	within
	rs73803631	4:24159527	A	0.91	2.08	0.45	4.5E-06	PPARGC1A	267827
	rs55699229	8:19114322	T	0.90	−2.25	0.47	1.7E-06	N/A	N/A
	rs75638212	10:22950466	T	0.86	−0.74	0.15	1.0E-06	PIP4K2A	within
	rs144212455	15:53363818	C	0.94	−2.59	0.54	1.9E-06	ONECUT1	281609
	rs4782614	16:84396105	A	0.32	0.57	0.12	2.5E-06	ATP2C2	6023
	rs71355331	18:45645902	T	0.94	1.12	0.24	3.6E-06	ZBTB7C	within
	rs199964754	18:63446314	T	0.51	1.42	0.30	2.4E-06	CDH7	within

^#: ancestry/phenotype; ^¶: Position: genome reference used hg19; ⁺: AF: allele frequency; ^§: distance from closest gene measured in base pairs; “within” denotes SNPs that are located within the gene.