TABLE 4

Multivariate Cox regression examining association between blood leukocyte indexes and 1) mortality in early fibrotic interstitial lung abnormalities (EF-ILA) (n=1259) and 2) radiological progression in the EF-ILA cohort with available repeat computed tomography scans for comparison (n=362)

	Mortality		Radiological progression
	HR (95% CI)	p-value	HR (95% CI)	p-value
MLR
Age	1.03 (1.01–1.06)	0.006*	1.02 (0.99–1.05)	0.113
Gender	1.00 (0.74–1.36)	0.995	0.92 (0.67–1.27)	0.624
MLR	1.16 (1.02–1.31)	0.025*	2.28 (1.33–3.87)	0.002*
NLR
Age	1.03 (1.01–1.06)	0.007*	1.02 (0.99–1.05)	0.122
Gender	0.98 (0.72–1.34)	0.910	0.96 (0.70–1.32)	0.814
NLR	1.07 (1.05–1.09)	<0.0001*	1.07 (1.01–1.14)	0.024*
SIRI
Age	1.04 (1.01–1.06)	0.003*	1.03 (0.99–1.05)	0.079*
Gender	1.02 (0.75–1.38)	0.924	0.96 (0.69–1.31)	0.789
SIRI	1.06 (1.04–1.08)	<0.0001*	1.09 (1.04–1.14)	0.0002*

Each leukocyte index, age and gender is a separate model. Similar findings were observed when leukocyte indexes were adjusted for respiratory comorbidity and when adjusted for coefficient of variation over a year (supplementary tables S3 and S4). MLR: monocyte:lymphocyte ratio; NLR: neutrophil:lymphocyte ratio; SIRI: systemic inflammatory response ((monocytes×neutrophils) ÷ lymphocytes). *: p<0.05.