Participant demographics and lung function

Participants (n)272016
Males/females (n)16/114/1612/4
Age (years)34 (19–65)43 (24–78)43 (27–54)+
BMI (kg·m−2)24.6±3.425.5±4.327.4±6.4
Smoking history (pack-years)19.3±8.6
Lung function
 FEV1 (% predicted)105.0±1489.2±1998.8±11§
 FVC (% predicted)105.0±1597.7±20105.5±11
 FEV1/FVC (%)83±6.074±8.476±6.0+
 TLC (% predicted)101±23103±18108±11
 FRCpleth (% predicted)97.0±2797.0±17109.1±19
DLCO (% predicted)102±1399±1590±12+
 FRCMBNW (L)#2.94±0.892.62±0.722.93±0.84
 LCI (TO)#6.49±0.477.23±1.047.05±0.82+
Scond (L−1)#0.019±0.0110.033±0.0180.038±0.019§
Sacin (L−1)#0.056±0.0200.086±0.0490.095±0.037+,§

Data are presented as mean±sd or median (interquartile range) unless otherwise stated. BMI: body mass index; DLCO: diffusing capacity of the lung for carbon monoxide; FEV1: forced expiratory volume in 1 s; FRC: functional residual capacity; FVC: forced vital capacity; LCI: lung clearance index; MBNW: multiple breath nitrogen washout; Sacin: distal/intra-acinar airways ventilation heterogeneity; Scond: conducting airways ventilation heterogeneity; TLC: total lung capacity; TO: lung turnover. #Corrected, controlled breathing protocol values used. p<0.05 health versus asthma. +p<0.05 health versus smokers. §p<0.05 asthma versus smokers.