TABLE 3

Pathophysiological features of type 2 inflammatory airway diseases [3, 31, 9299]

Asthma (IL-4, IL-13, IL-5)CRSwNP (IL-4, IL-13, IL-5)Allergic rhinitis (IL-4, IL-13, IL-5)
Inflammatory cell trafficking to the tissue
IgE production
Goblet cell hyperplasia/mucus production
Barrier dysfunction
Tissue remodelling
Smooth muscle proliferation/contractility
Inflammatory cell trafficking to the tissue
IgE production
Goblet cell hyperplasia/mucus production
Barrier dysfunction
Tissue remodelling
Microbiome alterations
Inflammatory cell trafficking to the tissue
IgE production
Goblet cell hyperplasia/mucus production
Barrier dysfunction

IL: interleukin; CRSwNP: chronic rhinosinusitis with nasal polyps.