TABLE 2

Cardiac catheterisation data at presentation

nSyncope at diagnosis#nSyncope on medication,+nNon-syncope§p-value
Baseline
 Mean RAP mmHg7 (5–10)7 (6–10)7 (6–9)0.86
 Mean PAP mmHg53 (37–65)66.5 (51.8–72)48.5 (36–64)0.18
 sPAP/sSAP0.80 (0.50–0.99)0.83 (0.76–1.10)660.75 (0.50–0.95)0.47
 PVRi WU·m213.7 (8.8–22.0)20.1 (9.2–25.1)669.05 (5.3–14.5)0.04
 Rp/Rs300.7 (0.5–1)50.7 (0.3–1.5)590.6 (0.33–0.94)0.42
 CI L·min−1·m−23.0 (2.2–3.8)2.8 (2.5–3.2)663.5 (2.5–4.2)0.19
AVT with iNO564
 Mean RAP mmHg256 (4–8.5)37 (2–8)447 (6–8.5)
 Mean PAP mmHg3538 (27–60)63 (53–66.5)37.5 (28–56.5)0.15
 sPAP/sSAP340.60 (0.40–0.92)0.77 (0.67–1.16)590.65 (0.46–0.89)0.30
 PVRi WU·m2339.3 (5.1–17.3)15.1 (11.9–19.5)616.5 (3.7–11)0.02
 Rp/Rs210.46 (0.29–0.72)N/A330.45 (0.21–0.83)0.99
 CI L·min−1·m−2333.2 (2.4–3.8)3.1 (2.7–3.8)583.6 (2.6–4.6)0.18
AVT responders (Barst)14 (40)015 (22)0.047
AVT responders (Sitbon)8 (23)09 (13)0.27

Data are expressed as median (interquartile range) or n (%). Bold p-values represent statistically significant differences. n: number of patients; RAP: right atrial pressure; PAP: pulmonary artery pressure; sPAP/sSAP: ratio of pulmonary artery/systemic arterial systolic pressure; PVRi: indexed pulmonary vascular resistance; Rp/Rs: ratio of pulmonary vascular resistance/systemic vascular resistance; CI: cardiac index; AVT: acute vasodilator testing; iNO: inhaled nitric oxide. #: n=36; : n=6; +: one patient with syncope on medication did not have a catheterisation available from the time of diagnosis; §: n=67.