Variable | Cluster A | Cluster B | p-value | |
Subjects n | 834 | 275 | ||
Order | ||||
1 | Trigger sum | 2.47±2.34 | 7.08±3.16 | 2.39×10−78 |
2 | LCQ physical domain | 5.38±0.68 | 4.21±0.81 | 1.02×10−75 |
3 | Number of cough background disorders | 0.82±0.78 | 1.99±0.89 | 9.09×10−65 |
4 | LCQ total score | 16.1±2.48 | 12.5±2.79 | 7.12×10−64 |
5 | Dyspnoea with wheezing | 8.4 | 55.0 | 3.38×10−61 |
6 | Paints or fumes as a cough trigger | 19.2 | 70.5 | 5.03×10−56 |
7 | Current asthma | 6.4 | 46.5 | 2.36×10−53 |
8 | LCQ social domain | 5.63±1.00 | 4.38±1.12 | 1.47×10−52 |
9 | Automobile exhaust fumes as a cough trigger | 13.4 | 59.3 | 4.37×10−52 |
10 | LCQ question 3 (tired because of cough)# | 5.93±1.07 | 4.57±1.36 | 2.36×10−48 |
23 | Symptom sum | 2.32±1.71 | 4.13±2.17 | 9.67×10−35 |
30 | LCQ question 2 (sputum production when coughing)# | 4.86±1.84 | 3.29±1.78 | 2.20×10−30 |
40 | Unexplained cough | 38.0 | 4.0 | 1.93×10−26 |
46 | Chronic rhinosinusitis | 13.9 | 41.8 | 1.15×10−22 |
47 | Allergy | 9.1 | 33.1 | 1.37×10−21 |
51 | Number of doctor's visits due to cough in the past 12 months | 0.40±1.15 | 1.24±2.19 | 4.49×10−19 |
53 | Presence of any trigger for cough | 71.8 | 96.7 | 1.11×10−17 |
56 | Speaking as a cough trigger | 16.4 | 40.4 | 2.98×10−16 |
61 | Family history of chronic cough | 31.8 | 58.0 | 2.03×10−14 |
70 | Gastro-oesophageal reflux disease | 22.3 | 43.8 | 8.87×10−12 |
77 | Sleep apnoea | 39.9 | 63.4 | 4.20×10−11 |
85 | Symptoms of flu at the beginning of the current cough | 13.9 | 30.7 | 6.65×10−10 |
86 | Number of cough episodes in the past 12 months | 4.92±7.90 | 7.39±8.98 | 1.03×10−9 |
105 | Duration of the cough episode | 1–5 years (2–12 months to 1–5 years) | 1–5 years (1–5 years to 5–10 years) | 1.29×10−5 |
107 | Use of cough medicines in the past 12 months | 28.2 | 42.4 | 1.82×10−5 |
114 | Female | 64.7 | 76.7 | 0.0003 |
115 | Autoimmune disorder | 18.2 | 28.0 | 0.0007 |
121 | COPD | 2.3 | 6.2 | 0.0029 |
124 | Bronchiectasis | 1.3 | 4.4 | 0.0046 |
138 | Body mass index (kg·m−2) | 27.7±4.5 | 28.2±5.4 | 0.19 |
146 | Pulmonary fibrosis | 0.8 | 1.8 | 0.30 |
149 | Age (years) | 72.8±5.2 | 73.1±5.4 | 0.36 |
150 | Current smoking | 1.8 | 2.9 | 0.38 |
Data are presented as either mean±sd, % or median (interquartile range), unless otherwise stated. The 10 most important variables and 23 variables of special interest expressed, in order of importance, as defined by the p-value obtained by Mann–Whitney U-test or Chi-squared test between the clusters. LCQ: Leicester Cough Questionnaire. #: LCQ questions have seven-step scales, from 1 (all of the time) to 7 (none of the time).