Fully adjusted linear regression models evaluating the association between ADI or CIMD and baseline FVC or DLCO

US cohortCanadian cohort
β95% CIp-valueβ95% CIp-value
Fully adjusted FVC model
 Continuous ADI (n=386) Continuous CIMD (n=102)
  Continuous ADI−0.06−0.14–0.020.14  Continuous CIMD2.27−4.19–8.740.49
 Quartiled ADI (n=386) Quartiled CIMD (n=102)
  Quartile 1reference  Quartile 1reference
  Quartile 2−2.07−7.04–2.910.41  Quartile 20.74−9.58–11.050.89
  Quartile 3−3.00−7.87–1.860.23  Quartile 30.42−9.74–10.570.94
  Quartile 4−1.66−6.80–3.480.53  Quartile 43.09−7.35–13.530.56
Fully adjusted DLCO model
 Continuous ADI (n=383) Continuous CIMD (n=87)
  Continuous ADI−0.10−0.20– −0.00040.049  Continuous CIMD−5.38−13.21–2.450.18
 Quartiled ADI (n=383) Quartiled CIMD (n=87)
  Quartile 1reference  Quartile 1reference
  Quartile 2−5.21−11.33–0.910.09  Quartile 21.95−10.34–14.240.75
  Quartile 3−4.51−10.48–1.460.14  Quartile 3−5.61−17.28–6.070.34
  Quartile 4−6.80−13.16– −0.440.04  Quartile 4−7.47−20.28–5.330.25

Fully adjusted models are adjusted for age at diagnosis, sex, smoking history and race. Quartile 1 reflects the lowest neighbourhood disadvantage, while quartile 4 reflects the highest disadvantage (worst). p-values <0.05 are bolded. ADI: area deprivation index; CIMD: Canadian Index of Multiple Deprivation; FVC: forced vital capacity; DLCO: diffusing capacity of the lung for carbon monoxide.