TABLE 2

Fully adjusted linear regression models evaluating the association between ADI or CIMD and baseline FVC or D_LCO

	US cohort				Canadian cohort
	β	95% CI	p-value		β	95% CI	p-value
Fully adjusted FVC model
Continuous ADI (n=386)				Continuous CIMD (n=102)
Continuous ADI	−0.06	−0.14–0.02	0.14	Continuous CIMD	2.27	−4.19–8.74	0.49
Quartiled ADI (n=386)				Quartiled CIMD (n=102)
Quartile 1	reference			Quartile 1	reference
Quartile 2	−2.07	−7.04–2.91	0.41	Quartile 2	0.74	−9.58–11.05	0.89
Quartile 3	−3.00	−7.87–1.86	0.23	Quartile 3	0.42	−9.74–10.57	0.94
Quartile 4	−1.66	−6.80–3.48	0.53	Quartile 4	3.09	−7.35–13.53	0.56
Fully adjusted D_LCO model
Continuous ADI (n=383)				Continuous CIMD (n=87)
Continuous ADI	−0.10	−0.20– −0.0004	0.049	Continuous CIMD	−5.38	−13.21–2.45	0.18
Quartiled ADI (n=383)				Quartiled CIMD (n=87)
Quartile 1	reference			Quartile 1	reference
Quartile 2	−5.21	−11.33–0.91	0.09	Quartile 2	1.95	−10.34–14.24	0.75
Quartile 3	−4.51	−10.48–1.46	0.14	Quartile 3	−5.61	−17.28–6.07	0.34
Quartile 4	−6.80	−13.16– −0.44	0.04	Quartile 4	−7.47	−20.28–5.33	0.25

Fully adjusted models are adjusted for age at diagnosis, sex, smoking history and race. Quartile 1 reflects the lowest neighbourhood disadvantage, while quartile 4 reflects the highest disadvantage (worst). p-values <0.05 are bolded. ADI: area deprivation index; CIMD: Canadian Index of Multiple Deprivation; FVC: forced vital capacity; D_LCO: diffusing capacity of the lung for carbon monoxide.