TABLE 2

Main data from comprehensive genetic analysis

Comparison	Gene	Log₂ (fold change)	p-value	Ranking^#
*Normal/vehicle versus* normal/PFD**	Nnmt	2.67	0.00000	27
*Normal/vehicle versus* low-niacin/vehicle**	Nnmt	1.87	0.00005	32
*Normal/PFD versus* low-niacin/PFD**	Neat1	1.99	0.00000	4
	Cyp7a1	−1.99	0.00000	5
	Socs2	1.63	0.00002	7
	Idi1	−1.58	0.00003	8
	Sult2a1	1.41	0.00008	12
	Slc25a30	1.44	0.00012	15
	Hgf	−1.28	0.00093	27
	Erbb4	−1.51	0.00212	37
	Fdps	−1.01	0.00427	49
*Low-niacin/vehicle versus* low-niacin/PFD**	Alas1	3.82	0.00000	3
	Lpin1	3.40	0.00000	4
	Mt2	3.26	0.00000	6
	Dbp	3.47	0.00000	8
	Chka	−3.48	0.00000	13
	Efna1	−3.40	0.00000	15
	Por	2.52	0.00000	17
	Socs2	2.68	0.00000	19
	Per1	2.64	0.00000	21
	Fkbp5	2.36	0.00000	23
	Fmo3	2.21	0.00000	26
	Pfkfb3	2.55	0.00000	27
	Arntl	−3.24	0.00000	29
	Cebpb	2.25	0.00000	32
	Thrsp	2.01	0.00000	35
	Wee1	2.43	0.00000	39
	St3gal5	1.90	0.00000	40
	Gadd45g	2.26	0.00000	42
	Fmo5	1.85	0.00000	43
	Angptl4	1.91	0.00000	45
	Stbd1	1.72	0.00001	50

^#: each gene was sorted by the p-value and the top 50 genes were ranked (supplementary tables S2–S5); the main genes of interest are listed here, ranked within each comparison. PFD: pirfenidone.