TABLE 2

Main data from comprehensive genetic analysis

ComparisonGeneLog2 (fold change)p-valueRanking#
Normal/vehicle versus normal/PFDNnmt2.670.0000027
Normal/vehicle versus low-niacin/vehicleNnmt1.870.0000532
Normal/PFD versus low-niacin/PFDNeat11.990.000004
Cyp7a1−1.990.000005
Socs21.630.000027
Idi1−1.580.000038
Sult2a11.410.0000812
Slc25a301.440.0001215
Hgf−1.280.0009327
Erbb4−1.510.0021237
Fdps−1.010.0042749
Low-niacin/vehicle versus low-niacin/PFDAlas13.820.000003
Lpin13.400.000004
Mt23.260.000006
Dbp3.470.000008
Chka−3.480.0000013
Efna1−3.400.0000015
Por2.520.0000017
Socs22.680.0000019
Per12.640.0000021
Fkbp52.360.0000023
Fmo32.210.0000026
Pfkfb32.550.0000027
Arntl−3.240.0000029
Cebpb2.250.0000032
Thrsp2.010.0000035
Wee12.430.0000039
St3gal51.900.0000040
Gadd45g2.260.0000042
Fmo51.850.0000043
Angptl41.910.0000045
Stbd11.720.0000150

#: each gene was sorted by the p-value and the top 50 genes were ranked (supplementary tables S2–S5); the main genes of interest are listed here, ranked within each comparison. PFD: pirfenidone.