Association between asthma and clinical worsening
| Multivariate analysis | OR (95% CI) | p-value |
| Unadjusted | 1.10 (0.94−1.28) | 0.235 |
| Adjusted on age, sex, current tobacco use and comorbidities | 1.23 (1.04−1.44) | 0.013 |
Comorbidities are body mass index (BMI), hypertension, diabetes, heart failure, COPD, coronary artery disease, cancer under treatment and chronic renal disease. Age and BMI as three categories (18–45 years, 46–65 years, >65 years and <25 kg m−2, 25–30 kg m−2, >30 kg m−2).