Association between asthma and clinical worsening

Multivariate analysisOR (95% CI)p-value
Unadjusted1.10 (0.94−1.28)0.235
Adjusted on age, sex, current tobacco use and comorbidities1.23 (1.04−1.44)0.013

Comorbidities are body mass index (BMI), hypertension, diabetes, heart failure, COPD, coronary artery disease, cancer under treatment and chronic renal disease. Age and BMI as three categories (18–45 years, 46–65 years, >65 years and <25 kg m−2, 25–30 kg m−2, >30 kg m−2).