TABLE 3

Fully adjusted linear mixed effects models with random intercept evaluating the association between ADI or CIMD and rate of change in FVC or D_LCO

	US cohort				Canadian cohort
	β	95% CI	p-value		β	95% CI	p-value
Fully adjusted FVC model
Continuous ADI (n=386)				Continuous CIMD (n=102)
Continuous ADI*time	−0.004	−0.008–0.001	0.11	Continuous CIMD*time	−0.47	−0.84– −0.10	0.006
Quartiled ADI (n=386)				Quartiled CIMD (n=102)
Quartile 1*time	reference			Quartile 1*time	reference
Quartile 2*time	−0.06	−0.34–0.23	0.69	Quartile 2*time	0.06	−0.59–0.72	0.85
Quartile 3*time	−0.03	−0.32–0.25	0.81	Quartile 3*time	−0.40	−1.01–0.20	0.19
Quartile 4*time	−0.40	−0.70– −0.11	0.007	Quartile 4*time	−0.80	−1.37– −0.24	0.003
Fully adjusted D_LCO model
Continuous ADI (n=383)				Continuous CIMD (n=87)
Continuous ADI*time	−0.008	−0.010–−0.003	0.005	Continuous CIMD*time	−0.39	−0.94–0.15	0.16
Quartiled ADI (n=383)				Quartiled CIMD (n=87)
Quartile 1*time	reference			Quartile 1*time	reference
Quartile 2*time	−0.76	−1.12– −0.41	<0.001	Quartile 2*time	−0.04	−0.99–0.91	0.93
Quartile 3*time	−0.51	−0.85– −0.16	0.004	Quartile 3*time	−0.35	−1.30–0.60	0.47
Quartile 4*time	−0.59	−0.95– −0.23	0.001	Quartile 4*time	−0.61	−1.45–0.24	0.16

Fully adjusted models are adjusted for age at diagnosis, sex, smoking history and race. Quartile 1 reflects the lowest neighbourhood disadvantage, while quartile 4 reflects the highest disadvantage (worst). p-values <0.05 are bolded. ADI: area deprivation index; CIMD: Canadian Index of Multiple Deprivation; FVC: forced vital capacity; D_LCO: diffusing capacity of the lung for carbon monoxide.