Fully adjusted linear mixed effects models with random intercept evaluating the association between ADI or CIMD and rate of change in FVC or DLCO

US cohortCanadian cohort
β95% CIp-valueβ95% CIp-value
Fully adjusted FVC model
 Continuous ADI (n=386) Continuous CIMD (n=102)
  Continuous ADI*time−0.004−0.008–0.0010.11  Continuous CIMD*time−0.47−0.84– −0.100.006
 Quartiled ADI (n=386) Quartiled CIMD (n=102)
  Quartile 1*timereference  Quartile 1*timereference
  Quartile 2*time−0.06−0.34–0.230.69  Quartile 2*time0.06−0.59–0.720.85
  Quartile 3*time−0.03−0.32–0.250.81  Quartile 3*time−0.40−1.01–0.200.19
  Quartile 4*time−0.40−0.70– −0.110.007  Quartile 4*time−0.80−1.37– −0.240.003
Fully adjusted DLCO model
 Continuous ADI (n=383) Continuous CIMD (n=87)
  Continuous ADI*time−0.008−0.010–−0.0030.005  Continuous CIMD*time−0.39−0.94–0.150.16
 Quartiled ADI (n=383) Quartiled CIMD (n=87)
  Quartile 1*timereference  Quartile 1*timereference
  Quartile 2*time−0.76−1.12– −0.41<0.001  Quartile 2*time−0.04−0.99–0.910.93
  Quartile 3*time−0.51−0.85– −0.160.004  Quartile 3*time−0.35−1.30–0.600.47
  Quartile 4*time−0.59−0.95– −0.230.001  Quartile 4*time−0.61−1.45–0.240.16

Fully adjusted models are adjusted for age at diagnosis, sex, smoking history and race. Quartile 1 reflects the lowest neighbourhood disadvantage, while quartile 4 reflects the highest disadvantage (worst). p-values <0.05 are bolded. ADI: area deprivation index; CIMD: Canadian Index of Multiple Deprivation; FVC: forced vital capacity; DLCO: diffusing capacity of the lung for carbon monoxide.