Parameter (unit) | gMean+ | gCV (%) |
Day 1# | ||
Cmax (nmol·L−1) | 277 | 23.1 |
AUCτ,1 (nmol·h·L−1) | 1990 | 18.2 |
Day 14¶ | ||
Cmax,ss (nmol·L−1) | 460 | 41.7 |
AUCτ,ss (nmol·h·L−1) | 3720 | 49.5 |
n=10. gMean: geometric mean; gCV: geometric coefficient of variation; Cmax: maximum measured concentration of the analyte in plasma; AUCτ,1: area under the concentration–time curve of the analyte in plasma over a uniform dosing interval τ after administration of the first dose; Cmax,ss: maximum measured concentration of analyte in plasma at steady state over a uniform dosing interval τ; AUCτ,ss: area under the concentration–time curve of the analyte in plasma at steady state over a uniform dosing interval τ at steady state. #: after the first dose; ¶: at steady state; +: n=10.