TABLE 1

Adherence terminology and nomenclature

TermDescription#
AdherenceProcess by which patients take their therapy (i.e. medications) as prescribed
 InitiationMoment at which the patient takes the first dose of a prescribed therapy and/or medication
 ImplementationExtent to which a patient's actual dosing corresponds to the prescribed dosing regimen from initiation until the last dose taken
 DiscontinuationBeing the end of therapy, when the next dose to be taken is omitted and no more doses are taken thereafter
 PersistenceLength of time between initiation and the last dose which immediately precedes discontinuation
ComplianceExtent to which patients follow healthcare provider directions
Patient expectationsAnticipation or belief of perceived benefit of therapy, related to adherence (i.e. patients may adhere well because of strong expectations for treatment success)
Dimensions of adherenceFactors related to maintenance of adherence as outlined by the World Health Organization
 PatientAge, socioeconomic group, motivation, knowledge of disease, perceived risks of disease, perceived benefit of treatment
 Healthcare systemPatient–provider relationship, care continuity, wait times
 ConditionSymptom severity, concurrent depression
 Social and economicCultural beliefs, language barriers, community support, therapy costs
 TherapyComplexity of medical regimen, duration of therapy, actual or perceived side-effects

#: adapted from [30, 50, 51].