TABLE 2

Bayesian linear mixed effects model estimates of per cent predicted forced expiratory volume in 1 s (FEV₁ % pred) (n=401, years of observation=3844)

	Unadjusted coefficient	95% CI	p-value	Adjusted coefficient^#	95% CI	p-value
Intercept	69.09	66.78–71.39	<0.001	70.97	68.52–73.42	<0.001
Time	−1.35	−1.54 – −1.15	<0.001*	−1.36	−1.55 – −1.17	<0.001*
CFTR modulator	1.51	0.49–2.48	0.002*	1.51	0.56–2.46	0.002*
Time : CFTR modulator	0.86	0.31–1.41	0.002*	0.88	0.35–1.39	0.001*

Interpretation: the intercept represents the mean FEV₁ % pred of the study population at the time of CFTR modulator initiation (baseline). The coefficient of time (in years) reflects the mean annual FEV₁ % pred decline in the years before CFTR modulator initiation. The coefficient CFTR modulator indicates the acute change in mean FEV₁ % pred after CFTR modulator initiation, whereas time : CFTR modulator represents the change in annual FEV₁ % pred decline in the years after CFTR modulator initiation compared to the years before. CFTR: cystic fibrosis transmembrane conductance regulator. ^#: coefficients were adjusted for the main effects of sex, age at baseline and the interaction effect of age at baseline with time; *: significance level p<0.05.