Findings suggestive for interstitial lung disease associated pulmonary hypertension
| Clinical | Bimalleolar oedema Jugular venous distension Signs of RV dysfunction |
| Pulmonary function tests | Disproportionately severe decrease in diffusing capacity of the lung, while lung volumes are normal or only modestly reduced |
| 6-min walk test | Lower than expected 6-min walk distance Marked exertional desaturation |
| Laboratory testing | Elevated (NT-pro)BNP Research: heart-type fatty acid binding protein, growth differentiation factor-15 |
| Chest imaging | Increased pulmonary artery to ascending aorta ratio (>0.9) Main pulmonary artery diameter >29 mm RV enlargement |
| Echocardiography | Peak tricuspid regurgitation velocity ≥2.8 m·s−1 RV/LV basal diameter ratio >1.0 Flattening of the interventricular septum RV outflow Doppler acceleration time <105 ms and/or midsystolic notching Pulmonary artery diameter >25 mm Inferior vena cava diameter >21 mm with decreased inspiratory collapse Right atrial area >18 cm2 |
RV: right ventricle; NT-proBNP: N-terminal pro-brain natriuretic peptide; LV: left ventricle.